ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012
Effect of tracer dose on left ventricular mechanical dyssynchrony indices by phase analysis of gated single photon emission computed tomography myocardial perfusion imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Diagnostic value of left ventricular dyssynchrony in patients with multivessel coronary artery disease and its impact on detecting patients with reduced left ventricular ejection fraction.Heart and vessels · 2026Article
- Clinical reference values for left ventricular function and synchronicity parameters evaluated by GMPI in patients with a low pretest likelihood of coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- Prognostic value of stress phase entropy for predicting major cardiac events in patients with known or suspected stable coronary artery disease.Heart and vessels · 2025Article
- Association between an Early Revascularization Strategy and Major Cardiac Events Based on Left Ventricular Dyssynchrony in Patients at Intermediate Risk of Major Cardiac Events Using the J-ACCESS Risk Model.Internal medicine (Tokyo, Japan) · 2024Article
- Assessing the diagnostic value of left ventricular synchrony indices derived from phase analysis by D-SPECT in identifying obstructive coronary artery disease.The international journal of cardiovascular imaging · 2024Article
- Low-dose dobutamine stress gated blood pool SPECT assessment of left ventricular contractile reserve in ischemic cardiomyopathy: a feasibility study.European journal of nuclear medicine and molecular imaging · 2022Article
- Prognostic Significance of Left Ventricular Dyssynchrony Assessed with Nuclear Cardiology for the Prediction of Major Cardiac Events after Revascularization.Internal medicine (Tokyo, Japan) · 2021Article
- Are SPECT MPI measures of dyssynchrony dyssynchronous?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Comparison of the dyssynchrony parameters recorded with gated SPECT in ischemic cardiomyopathy according to their repeatability at rest and to their ability to detect a synchrony reserve under dobutamine infusion.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Auxiliary ischemic markers, the role of left ventricular dyssynchrony.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Left ventricular mechanical dyssynchrony graduation of myocardial perfusion gated SPECT phase analysis: What next.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Comparison of diagnostic performance of four software packages for phase dyssynchrony analysis in gated myocardial perfusion SPECT.EJNMMI research · 2017Article
- Early post-stress LV dyssynchrony: a new marker for significant CAD.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Prognostic value of left ventricular mechanical dyssynchrony by phase analysis in patients with non-ischemic cardiomyopathy with ejection fraction 35-50% and QRS < 150 ms.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Safety and tolerability of regadenoson in 514 SPECT MPI patients with and without coronary artery disease and submaximal exercise heart rate response.European journal of nuclear medicine and molecular imaging · 2013Article
- Paradoxical septal motion from prior coronary artery bypass graft surgery does not impact left ventricular mechanical dyssynchrony by gated myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- Left ventricular dyssynchrony assessed by gated SPECT phase analysis is an independent predictor of death in patients with advanced coronary artery disease and reduced left ventricular function not undergoing cardiac resynchronization therapy.European journal of nuclear medicine and molecular imaging · 2012Article
- Alternative methods for the assessment of mechanical dyssynchrony using phase analysis of gated single photon emission computed tomography myocardial perfusion imaging.The international journal of cardiovascular imaging · 2012Article
- Effect of stress testing on left ventricular mechanical synchrony by phase analysis of gated positron emission tomography in patients with normal myocardial perfusion.European journal of nuclear medicine and molecular imaging · 2012Article
- Normal values of cardiac mechanical synchrony parameters using gated myocardial perfusion single-photon emission computed tomography: Impact of population and study protocol.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are limited data on the effect of tracer dose on the reproducibility and accuracy of left ventricular (LV) mechanical dyssynchrony indices by phase analysis of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). METHODS AND
resultsWe measured LV dyssynchrony in 54 patients with normal LV ejection and perfusion (group 1) and 54 age and gender matched patients with LV ejection <35% (group 2) using phase analysis of gated SPECT MPI from stress (high dose) and rest (low dose) studies with 2 software programs: Corridor4DM (4DM) and Emory Cardiac Toolbox (ECTb). Although the correlation between rest- and stress-derived standard deviation was good (R = 0.76, P < .0001, with both software programs), there was considerable variability between the measurements (P < .0001 by paired t test). In addition, the rest standard deviation was significantly higher than stress in group 1 (10.2° ± 4.6° vs 6.1° ± 2.5°, and 12.2° ± 6.4° vs 7.9° ± 4.6°, with 4DM and ECTb, respectively, P < .0001 for both) and group 2 patients (44.0° ± 18.0° vs 35.9° ± 21.0° and 47.3° ± 19.2° vs 38.8° ± 19.8°, with 4DM and ECTb, P = .03 and .02, respectively). Similarly, the rest standard deviations were higher than the stress values irrespective of the type of stress test (i.e., exercise vs pharmacological), and the body mass index. Finally, using rest-derived dyssynchrony indices was associated with 9%-13% and 22%-26% false positive rate of significant mechanical dyssynchrony using different cut-off values for groups 1 and 2, respectively.
conclusionLV mechanical dyssynchrony indices by phase analysis have more variation and are significantly higher if derived from rest gated SPECT images obtained with low-dose tracer.
Indexed as
Identifiers
22037814What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.