ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2012
The effect of local anesthetic and corticosteroid combinations on chondrocyte viability.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- The effects of ultrasound-guided corticosteroid injection compared to oxygen-ozone (OClinical rheumatology · 2018Trial
- Non-Biologic Injections in Sports Medicine.Current reviews in musculoskeletal medicine · 2026Review
- From Physicochemical Properties to Rehabilitation Outcomes: Understanding Corticosteroid Injection Adverse Effects.International journal of molecular sciences · 2026Review
- Femoroacetabular Impingement: Critical Analysis Review of Current Nonoperative Treatments.JBJS reviews · 2025Review
- Chondrotoxicity of Intra-Articular Injection Treatment: A Scoping Review.International journal of molecular sciences · 2024Article
- Injections prior to hip arthroscopy are associated with increased risk of repeat hip arthroscopy at 1 and 5 years.Archives of orthopaedic and trauma surgery · 2024Article
- FactFinders for patient safety: Preventing local anesthetic-related complications: Local anesthetic chondrotoxicity and stellate ganglion blocks.Interventional pain medicine · 2023Article
- Management of Patients with Adhesive Capsulitis via Ultrasound-Guided Hydrodilatation without Concomitant Intra-Articular Lidocaine Infusion: A Single-Center Experience.Life (Basel, Switzerland) · 2022Article
- Dexamethasone Does not Compensate for Local Anesthetic Cytotoxic Effects on Tenocytes: Morphine or Morphine Plus Dexamethasone May Be a Safe Alternative.Arthroscopy, sports medicine, and rehabilitation · 2022Article
- Hyaluronic Acid as a Carrier Supports the Effects of Glucocorticoids and Diminishes the Cytotoxic Effects of Local Anesthetics in Human Articular Chondrocytes In Vitro.International journal of molecular sciences · 2021Article
- Article
- In vitro chondrocyte toxicity following long-term, high-dose exposure to Gd-DTPA and a novel cartilage-targeted MR contrast agent.Skeletal radiology · 2017Article
- Multipotent Mesenchymal Stem Cell Treatment for Discogenic Low Back Pain and Disc Degeneration.Stem cells international · 2016Review
- Ultrasound guided intra-articular ketorolac versus corticosteroid injection in osteoarthritis of the hip: a retrospective comparative study.Skeletal radiology · 2015Article
- Reduction of environmental temperature mitigates local anesthetic cytotoxicity in bovine articular chondrocytes.Journal of sports science & medicine · 2014Article
- Limited therapeutic benefits of intra-articular cortisone injection for patients with femoro-acetabular impingement and labral tear.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Article
- Co-administration of hyaluronic acid with local anaesthetics shows lower cytotoxicity than local anaesthetic treatment alone in bovine articular chondrocytes.Bone & joint research · 2013Article
- Management of cartilage defects in the shoulder.Current reviews in musculoskeletal medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLocal anesthetic and corticosteroid combination injections are often used in clinical practice, however research investigating the chondrotoxic properties of these combinations is minimal. The goal of this study was to evaluate the effect of single injection doses of 1% lidocaine or 0.25% bupivacaine in combination with single injection doses of dexamethasone sodium phosphate (Decadron), methylprednisolone acetate (Depo-Medrol), betamethasone sodium phosphate and betamethasone acetate (Celestone Soluspan), or triamcinolone acetonide (Kenalog) on human chondrocyte viability.
methodsAll treatment conditions were delivered to human chondrocytes in vitro for the medication's respective average duration of action using a bioreactor containing a continuous infusion pump constructed to mimic joint fluid metabolism. A two-color fluorescence assay was used to evaluate cell viability. A mixed-effects regression model was used to evaluate the mean differences in cell viability between treatment groups.
resultsAt 14 days, a single injection dose of 1% lidocaine or 0.25% bupivacaine in combination with betamethasone sodium phosphate and betamethasone acetate solution illustrated significant chondrotoxicity when compared with the local anesthetics alone (P < 0.01). Methylprednisolone acetate and Triamcinolone acetonide both showed significant evidence of chondrotoxicity (P = 0.013; P = 0.016, respectively) when used in combination with 1% lidocaine compared with lidocaine alone, but showed no significant chondrotoxicity in combination with 0.25% bupivacaine (P's = n.s.).
conclusionsClinicians should use caution when injecting 1% lidocaine or 0.25% bupivacaine in conjunction with betamethasone sodium phosphate and betamethasone acetate solution due to its pronounced chondrotoxic effect in this study. 1% lidocaine used in combination with methylprednisolone acetate or triamcinolone acetonide also led to significant chondrotoxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.