Evidence map›Paper›PMID 22037809›Full record

ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2012

Non-surgical management of early knee osteoarthritis.

Elizaveta Kon, Giuseppe Filardo, Matej Drobnic, Henning Madry, Mislav Jelic, Niek van Dijk, Stefano Della Villa

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05160441 (A Prospective, Single-blind, Randomized, Multi-Center Study Comparing Platelet Rich Plasma and Corticosteroid for Patients With Glenohumeral Osteoarthritis in the Military and Civilian Population), which is not on this map. Cited by 80 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05160441 phase3completednot on this mapstarted 2022, after this paper: background citation

A Prospective, Single-blind, Randomized, Multi-Center Study Comparing Platelet Rich Plasma and Corticosteroid for Patients With Glenohumeral Osteoarthritis in the Military and Civilian Population

TypeinterventionalSponsorWalter Reed National Military Medical CenterRan2022 to 2025Enrolled50ConditionsOsteoarthritis of the Shoulder, Corticosteroid, PRP, PainArmsPlatelet Rich Plasma Injection, Corticosteroid Injection, Delayed Platelet Rich Plasma Injection After Corticosteroid Injection Failure
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  5. Stem cells in articular cartilage regeneration.Journal of orthopaedic surgery and research · 2016
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  8. Arthroscopic surgery for degenerative tears of the meniscus: a systematic review and meta-analysis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizaveta KonBiomechanics Laboratory - III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano,1/10, 40136, Bologna, Italy. e.kon@biomec.ior.it
Giuseppe Filardo
Matej Drobnic
Henning Madry
Mislav Jelic
Niek van Dijk
Stefano Della Villa

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conservative approach is usually the first choice for the management of the knee degeneration processes, especially in the phase of the disease recognized as early osteoarthritis (OA) with no clear lesions or associated abnormalities requiring to be addressed surgically. A wide spectrum of treatments is available, from non-pharmacological modalities to dietary supplements and pharmacological therapies, as well as minimally invasive procedures involving injections of various substances aiming to restore joint homeostasis and provide clinical improvement and possibly a disease-modifying effect. Numerous pharmaceuticals have been proposed, but since no therapy has shown all the characteristic of an ideal treatment, and side effects have been reported at both systemic and local level, the use of pharmacological agents should be considered with caution by assessing the risk/benefit ratio of the drugs prescribed. Both patients and physicians should have realistic outcome goals in pharmacological treatment, which should be considered together with other conservative measures. A combination of these therapeutic options is a more preferable scenario, in particular considering the evidence available for non-pharmacological management. In fact, exercise is an effective conservative approach, even if long-term effectiveness and optimal dose and administration modalities still need to be clarified. Finally, physical therapies are emerging as viable treatment options, and novel biological approaches are under study. Further studies to increase the limited medical evidence on conservative treatments, optimizing results, application modalities, indications, and focusing on early OA will be necessary in the future. Level of evidence IV.

Indexed as

Administration, OralAdministration, TopicalAdrenal Cortex HormonesAnti-Inflammatory Agents, Non-SteroidalCartilage, ArticularDisease ProgressionExercise TherapyHumansHyaluronic AcidMesenchymal Stem Cell TransplantationOsteoarthritis, KneePhysical Therapy ModalitiesS-AdenosylmethionineViscosupplementationAdrenal Cortex HormonesAnti-Inflammatory Agents, Non-SteroidalHyaluronic AcidhylanS-Adenosylmethionine

Identifiers

PMID22037809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.