Evidence map›Paper›PMID 22037798›Full record

ReviewMolecular neurobiology2011

Neurexins and neuroligins: recent insights from invertebrates.

David Knight, Wei Xie, Gabrielle L Boulianne

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. AiScience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. A Rare Case of Dysmorphism with Duplication in Chromosome 22.Indian journal of clinical biochemistry : IJCB · 2022
    Article
  7. Review
  8. Neuroligin-1 Is a Mediator of Methylmercury Neuromuscular Toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Functional mosaic organization of neuroligins in neuronal circuits.Cellular and molecular life sciences : CMLS · 2020
    Review
  17. Abnormal Social Interactions in aInternational journal of molecular sciences · 2020
    Article
  18. Article
  19. Review
  20. A subset of brain neurons controls regurgitation in adultThe Journal of experimental biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

David KnightProgram in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Wei Xie
Gabrielle L Boulianne
Hospital for Sick Children · CASoutheast University · CNUniversity of Toronto · CA

Funding

Canadian Institutes of Health Research MOP 14143
6 · The paper itself

Abstract

During brain development, each neuron must find and synapse with the correct pre- and postsynaptic partners. The complexity of these connections and the relatively large distances some neurons must send their axons to find the correct partners makes studying brain development one of the most challenging, and yet fascinating disciplines in biology. Furthermore, once the initial connections have been made, the neurons constantly remodel their dendritic and axonal arbours in response to changing demands. Neurexin and neuroligin are two cell adhesion molecules identified as important regulators of this process. The importance of these genes in the development and modulation of synaptic connectivity is emphasised by the observation that mutations in these genes in humans have been associated with cognitive disorders such as Autism spectrum disorders, Tourette syndrome and Schizophrenia. The present review will discuss recent advances in our understanding of the role of these genes in synaptic development and modulation, and in particular, we will focus on recent work in invertebrate models, and how these results relate to studies in mammals.

Indexed as

AnimalsCalcium-Binding ProteinsCell Adhesion Molecules, NeuronalHumansInvertebratesMutationNerve Tissue ProteinsNeural Cell Adhesion MoleculesNeuromuscular JunctionNeuronsPhylogenySynapsesCalcium-Binding ProteinsCell Adhesion Molecules, NeuronalNerve Tissue ProteinsNeural Cell Adhesion Moleculesneuroligin 1NRXN1 protein, human

Identifiers

PMID22037798
PMCPMC3229692
OpenAlexW2095284296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.