ArticleMolecular and cellular biology2012
Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development.
Article in Molecular and cellular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- RNA processing mechanisms contribute to genome organization and stability in B cells.Oncogene · 2024Review
- A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells.Cellular & molecular immunology · 2023Article
- The IgHFrontiers in immunology · 2023Article
- Reversal of splicing infidelity is a pre-activation step in B cell differentiation.Frontiers in immunology · 2022Article
- Contribution of Immunoglobulin Enhancers to B Cell Nuclear Organization.Frontiers in immunology · 2022Review
- Modulation of alternative splicing during early infection of human primary B lymphocytes with Epstein-Barr virus (EBV): a novel function for the viral EBNA-LP protein.Nucleic acids research · 2021Article
- Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphocytes.International journal of molecular sciences · 2020Review
- The Yin and Yang of RNA surveillance in B lymphocytes and antibody-secreting plasma cells.BMB reports · 2019Review
- Physiological and druggable skipping of immunoglobulin variable exons in plasma cells.Cellular & molecular immunology · 2019Article
- Biology of RNA Surveillance in Development and Disease.Trends in cell biology · 2019Review
- Comprehensive molecular characterization of a heavy chain deposition disease case.Haematologica · 2018Article
- The role of B cell antigen receptors in mantle cell lymphoma.Journal of hematology & oncology · 2017Review
- Structure and diversification of immunoglobulin genes in African Burkitt lymphoma.Blood advances · 2017Article
- Review
- Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.Nature communications · 2016Article
- A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production.The Journal of experimental medicine · 2016Article
- Pronounced cohabitation of active immunoglobulin genes from three different chromosomes in transcription factories during maximal antibody synthesis.Genes & development · 2014Article
- Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells.Nucleic acids research · 2013Article
- The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells.The Journal of experimental medicine · 2013Article
- Post-transcriptional regulatory networks in immunity.Immunological reviews · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin (Ig) genes naturally acquire frequent premature termination codons during the error-prone V(D)J recombination process. Although B cell differentiation is linked to the expression of productive Ig alleles, the transcriptional status of nonfunctionally recombined alleles remains unclear. Here, we tracked transcription and posttranscriptional regulation for both Ig heavy-chain (IgH) alleles in mice carrying a nonfunctional knock-in allele. We show that productively and nonproductively VDJ-rearranged alleles are transcribed throughout B cell development, carry similar active chromatin marks, and even display equivalent RNA polymerase II (RNAPII) loading after B cell stimulation. Hence, these results challenge the idea that the repositioning of one allele to heterochromatin could promote the silencing of nonproductive alleles. Interestingly, the efficiency of downstream RNA surveillance mechanisms fluctuates according to B cell activation and terminal differentiation: unspliced nonfunctional transcripts accumulate in primary B cells, while B cell activation promotes IgH transcription, RNA splicing, and nonsense-mediated mRNA decay (NMD). Altogether, IgH transcription and RNA splicing rates determine by which RNA surveillance mechanisms a B cell can get rid of nonproductive IgH mRNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.