Evidence map›Paper›PMID 22037739›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2011

Latent cytomegalovirus infection is an independent risk factor for late graft failure in renal transplant recipients.

Rutger M van Ree, Aiko P J de Vries, Dorien M Zelle, Laura V de Vries, Leendert H Oterdoom, Reinold O B Gans, Jan P Schouten, Simon P M Lems, Willem J van Son, Stephan J L Bakker

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03272854 (TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03272854 active not recruitingnot on this map

TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study

Typeobservational_patient_registrySponsorUniversity Medical Center GroningenRan2001 to 2031Enrolled606ConditionsDeath, Graft Failure, Death, Cardiac, DiabetesArmsNo intervention performed, the study is observational
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  3. Article
  4. NK cell and Th17 responses are differentially induced in murine cytomegalovirus infected renal allografts and vary according to recipient virus dose and strain.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rutger M van ReeRenal Transplant Program, University Medical Center Groningen and University of Groningen, The Netherlands.
Aiko P J de Vries
Dorien M Zelle
Laura V de Vries
Leendert H Oterdoom
Reinold O B Gans
Jan P Schouten
Simon P M Lems
Willem J van Son
Stephan J L Bakker
University Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytomegalovirus (CMV) is a risk factor for rejection and mortality soon after renal transplantation. Little is known about its consequences longer after transplantation. We prospectively investigated whether latent CMV infection is a risk factor for graft failure and mortality long after transplantation. MATERIAL/

methodsOur study included 606 renal transplant recipients (RTR) with a functioning graft for >1 year. CMV serology was determined using ELISA. RTRs were divided into CMV-seronegative and latent CMV (seropositive + seroconverted).

resultsWe measured CMV IgG at 6.0 [2.6-11.4] years post-transplant. During follow-up (7.0 [6.2-7.5] years), 54 (9%) RTRs experienced graft failure and 137 (23%) RTRs died. Risk for graft failure and mortality was significantly higher in RTRs with latent CMV compared to CMV-seronegative RTRs (HR=3.1, P=0.005 and HR=2.0, P=0.002, respectively). After adjustment for potential confounders, latent CMV infection remained an independent risk factor for graft failure (HR=4.6, P=0.001), but not for mortality (HR=1.4, P=0.2).

conclusionsLatent CMV is an independent risk factor for graft failure long after renal transplantation and carries a higher risk for graft failure than for mortality. These findings confirm the notion that latent CMV can be harmful in transplanted kidneys.

Indexed as

Cohort StudiesCytomegalovirus InfectionsEnzyme-Linked Immunosorbent AssayGraft RejectionHumansImmunoglobulin GKidney TransplantationLinear ModelsProspective StudiesRisk FactorsStatistics, NonparametricImmunoglobulin G

Identifiers

PMID22037739
PMCPMC3539501
OpenAlexW2112041990

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.