ArticleEcotoxicology (London, England)2012
Transgenic nematodes as biosensors for metal stress in soil pore water samples.
Article in Ecotoxicology (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Reproductive-Toxicity-Related Endpoints inJournal of developmental biology · 2023Article
- Biomonitoring of Indoor Air Fungal or Chemical Toxins withPathogens (Basel, Switzerland) · 2023Article
- phiC31 integrase for recombination-mediated single-copy insertion and genome manipulation in Caenorhabditis elegans.Genetics · 2022Article
- Effect of 9,12-Octadecadiynoic Acid on Neurobehavioral Development inInternational journal of molecular sciences · 2021Article
- Sulforaphane promotesAging · 2021Article
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- Air Pollution Alters Caenorhabditis elegans Development and Lifespan: Responses to Traffic-Related Nanoparticulate Matter.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Review
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- Induction of Metallothionein Expression After Exposure to Conventional Cigarette Smoke but Not Electronic Cigarette (ECIG)-Generated Aerosol inFrontiers in physiology · 2018Article
- Toxicity profile of organic extracts from Magdalena River sediments.Environmental science and pollution research international · 2018Article
- Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage.Antioxidants & redox signaling · 2017Article
- Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans.BMC pharmacology & toxicology · 2016Article
- Metallothioneins act downstream of insulin signaling to regulate toxicity of outdoor fine particulate matter (PMToxicology research · 2016Article
- Biosafety assessment of GFP transplastomic tobacco to rhizosphere microbial community.Ecotoxicology (London, England) · 2014Article
- Article
- Article
- Use of transgenic GFP reporter strains of the nematode Caenorhabditis elegans to investigate the patterns of stress responses induced by pesticides and by organic extracts from agricultural soils.Ecotoxicology (London, England) · 2013Article
- Effects of α-synuclein overexpression in transgenic Caenorhabditis elegans strains.CNS & neurological disorders drug targets · 2012Article
- Genome-Wide Analyses of Metal Responsive Genes in Caenorhabditis elegans.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caenorhabditis elegans strains carrying stress-reporter green fluorescent protein transgenes were used to explore patterns of response to metals. Multiple stress pathways were induced at high doses by most metals tested, including members of the heat shock, oxidative stress, metallothionein (mtl) and xenobiotic response gene families. A mathematical model (to be published separately) of the gene regulatory circuit controlling mtl production predicted that chemically similar divalent metals (classic inducers) should show additive effects on mtl gene induction, whereas chemically dissimilar metals should show interference. These predictions were verified experimentally; thus cadmium and mercury showed additive effects, whereas ferric iron (a weak inducer) significantly reduced the effect of mercury. We applied a similar battery of tests to diluted samples of soil pore water extracted centrifugally after mixing 20% w/w ultrapure water with air-dried soil from an abandoned lead/zinc mine in the Murcia region of Spain. In addition, metal contents of both soil and soil pore water were determined by ICP-MS, and simplified mixtures of soluble metal salts were tested at equivalent final concentrations. The effects of extracted soil pore water (after tenfold dilution) were closely mimicked by mixtures of its principal component ions, and even by the single most prevalent contaminant (zinc) alone, though other metals modulated its effects both positively and negatively. In general, mixtures containing similar (divalent) metal ions exhibited mainly additive effects, whereas admixture of dissimilar (e.g. trivalent) ions often resulted in interference, reducing overall levels of stress-gene induction. These findings were also consistent with model predictions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.