ArticleDevelopmental biology2012
Intramuscular adipose is derived from a non-Pax3 lineage and required for efficient regeneration of skeletal muscles.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 78 citations in OpenAlex.
- Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro-Regenerative Versus Maladaptive.Journal of cachexia, sarcopenia and muscle · 2026Review
- Epicardial Adipocytes in Cardiac Pathology and Healing.Cardiovascular drugs and therapy · 2025Review
- Intramuscular adipose tissue restricts functional muscle recovery.Cell reports · 2025Article
- Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling.Molecular aspects of medicine · 2024Review
- The Notch-PDGFRβ axis suppresses brown adipocyte progenitor differentiation in early post-natal mice.Developmental cell · 2024Article
- Review
- Development and expansion of intramuscular adipose tissue is not dependent on UCP-1-lineage cells in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration.Nature communications · 2023Article
- Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration.Journal of visualized experiments : JoVE · 2023Article
- MMECommunications biology · 2023Article
- IMFSegNet: Cost-effective and objective quantification of intramuscular fat in histological sections by deep learning.Computational and structural biotechnology journal · 2023Article
- Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms.Frontiers in endocrinology · 2023Review
- Thermogenic adipose tissue in energy regulation and metabolic health.Frontiers in endocrinology · 2023Review
- Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage.NPJ Regenerative medicine · 2022Article
- A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle.Journal of visualized experiments : JoVE · 2022Article
- Skeletal muscle-targeted delivery of Fgf6 protects mice from diet-induced obesity and insulin resistance.JCI insight · 2021Article
- Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors-time for new definitions.Skeletal muscle · 2021Review
- Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle.Scientific reports · 2021Article
- Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease.Human genetics · 2021Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Ectopic accumulation of adipose in the skeletal muscle is associated with muscle wasting, insulin resistance and diabetes. However, the developmental origin of postnatal intramuscular adipose and its interaction with muscle tissue are unclear. We report here that compared to the fast EDL muscles, slow SOL muscles are more enriched with adipogenic progenitors and have higher propensity to form adipose. Using Cre/LoxP mediated lineage tracing in mice, we show that intramuscular adipose in both EDL and SOL muscles is exclusively derived from a Pax3(-) non-myogenic lineage. In contrast, inter-scapular brown adipose is derived from the Pax3(+) lineage. To dissect the interaction between adipose and skeletal muscle tissues, we used Myf5-Cre and aP2-Cre mice in combination with ROSA26-iDTR mice to genetically ablate myogenic and adipogenic cell lineages, respectively. Whereas ablation of the myogenic cell lineage facilitated adipogenic differentiation, ablation of the adipogenic cell lineage surprisingly impaired the regeneration of acutely injured skeletal muscles. These results reveal striking heterogeneity of tissue-specific adipose and a previously unappreciated role of intramuscular adipose in skeletal muscle regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.