ArticlePharmacology, biochemistry, and behavior2012
Running wheel activity protects against increased seizure susceptibility in ethanol withdrawn male rats.
Article in Pharmacology, biochemistry, and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The impact of intermittent exercise on mouse ethanol drinking and abstinence-associated affective behavior and physiology.Alcoholism, clinical and experimental research · 2022Article
- Exercise as a Sex-Specific Treatment for Substance Use Disorder.Current addiction reports · 2017Article
- Wheel running reduces ethanol seeking by increasing neuronal activation and reducing oligodendroglial/neuroinflammatory factors in the medial prefrontal cortex.Brain, behavior, and immunity · 2016Article
- Sex differences in drug addiction and response to exercise intervention: From human to animal studies.Frontiers in neuroendocrinology · 2016Review
- Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis.Neuroscience and biobehavioral reviews · 2013Review
- Voluntary wheel running attenuates ethanol withdrawal-induced increases in seizure susceptibility in male and female rats.Pharmacology, biochemistry, and behavior · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Ethanol withdrawal is a dysphoric condition that arises from termination of ethanol intake by dependent individuals. Common withdrawal symptoms include anxiety, increased reactivity to stimuli and increased seizure susceptibility as well as the risk of increased seizure severity. We use an animal model of dependence and withdrawal to study withdrawal behaviors and potential underlying neurobiological mechanisms. For a number of years, we have quantified pentylenetetrazol seizure thresholds as an assessment of ethanol withdrawal at both one day and three days of withdrawal. Typically, we see a significant decrease in seizure threshold (increased sensitivity to seizure induction) that persists through three days of withdrawal for male rats. Increasing evidence indicates that voluntary exercise affords protection against various challenges to physical and psychological health, including ethanol-related challenges. Therefore, the current study investigated the effect of voluntary wheel running on seizure susceptibility following chronic ethanol administration and withdrawal. We found that voluntary wheel running attenuated the increased sensitivity to pentylenetetrazol-induced seizures observed with ethanol withdrawal, at both the one-day and three-day time points. This result was especially interesting as animals with access to the running wheels consumed more of the ethanol-containing diet. These findings showed that chronic voluntary wheel running reduces the severity of ethanol withdrawal in our animal model and suggest that exercise-based interventions may have some utility in the clinical management of heavy drinking and alcohol withdrawal.
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