ArticleJournal of bacteriology2012
Comprehensive transcriptome analysis of the periodontopathogenic bacterium Porphyromonas gingivalis W83.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Defining the role of Hmu and Hus systems in Porphyromonas gingivalis heme and iron homeostasis and virulence.Scientific reports · 2024Article
- Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution.Microbiology and molecular biology reviews : MMBR · 2024Review
- A quantitative framework reveals traditional laboratory growth is a highly accurate model of human oral infection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- PgFur participates differentially in expression of virulence factors in more virulent A7436 and less virulent ATCC 33277 Porphyromonas gingivalis strains.BMC microbiology · 2019Article
- Gene expression of Porphyromonas gingivalis ATCC 33277 when growing in an in vitro multispecies biofilm.PloS one · 2019Article
- Genomic repeats, misassembly and reannotation: a case study with long-read resequencing of Porphyromonas gingivalis reference strains.BMC genomics · 2018Article
- Transcriptomic response to GABA-producing Lactobacillus plantarum CGMCC 1.2437T induced by L-MSG.PloS one · 2018Article
- Worlds Apart - Transcriptome Profiles of Key Oral Microbes in the Periodontal Pocket Compared to Single Laboratory Culture Reflect Synergistic Interactions.Frontiers in microbiology · 2018Article
- Comparative gene expression analysis of Porphyromonas gingivalis ATCC 33277 in planktonic and biofilms states.PloS one · 2017Article
- High-throughput sequencing reveals key genes and immune homeostatic pathways activated in myeloid dendritic cells by Porphyromonas gingivalis 381 and its fimbrial mutants.Molecular oral microbiology · 2016Article
- Article
- CeCaFDB: a curated database for the documentation, visualization and comparative analysis of central carbon metabolic flux distributions explored by 13C-fluxomics.Nucleic acids research · 2015Article
- Transcriptome dynamics-based operon prediction in prokaryotes.BMC bioinformatics · 2014Article
- Identification and characterization of prokaryotic dipeptidyl-peptidase 5 from Porphyromonas gingivalis.The Journal of biological chemistry · 2014Article
- Article
- Comprehensive analysis of the Corynebacterium glutamicum transcriptome using an improved RNAseq technique.BMC genomics · 2013Article
- Directional RNA-seq reveals highly complex condition-dependent transcriptomes in E. coli K12 through accurate full-length transcripts assembling.BMC genomics · 2013Article
- Genetic diversity in the oral pathogen Porphyromonas gingivalis: molecular mechanisms and biological consequences.Future microbiology · 2013Review
- Article
- Regulon controlled by the GppX hybrid two component system in Porphyromonas gingivalis.Molecular oral microbiology · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
High-density tiling microarray and RNA sequencing technologies were used to analyze the transcriptome of the periodontopathogenic bacterium Porphyromonas gingivalis. The compiled P. gingivalis transcriptome profiles were based on total RNA samples isolated from three different laboratory culturing conditions, and the strand-specific transcription profiles generated covered the entire genome, including both protein coding and noncoding regions. The transcription profiles revealed various operon structures, 5'- and 3'-end untranslated regions (UTRs), differential expression patterns, and many novel, not-yet-annotated transcripts within intergenic and antisense regions. Further transcriptome analysis identified the majority of the genes as being expressed within operons and most 5' and 3' ends to be protruding UTRs, of which several 3' UTRs were extended to overlap genes carried on the opposite/antisense strand. Extensive antisense RNAs were detected opposite most insertion sequence (IS) elements. Pairwise comparative analyses were also performed among transcriptome profiles of the three culture conditions, and differentially expressed genes and metabolic pathways were identified. With the growing realization that noncoding RNAs play important biological functions, the discovery of novel RNAs and the comprehensive transcriptome profiles compiled in this study may provide a foundation to further understand the gene regulation and virulence mechanisms in P. gingivalis. The transcriptome profiles can be viewed at and downloaded from the Microbial Transcriptome Database website, http://bioinformatics.forsyth.org/mtd.
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