ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Systematic review and meta-analysis of nitrates/nitrites in patients with heart failure or pulmonary hypertension.European journal of medical research · 2025Pooled it
- Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults.European journal of applied physiology · 2020Trial
- PlanHabThe Journal of physiology · 2018Trial
- Functional, histological, and molecular adaptations of forelimb muscles in a rat model of monocrotaline-induced heart failure.Histochemistry and cell biology · 2025Article
- Reduced exercise capacity occurs before intrinsic skeletal muscle dysfunction in experimental rat models of pulmonary hypertension.Pulmonary circulation · 2024Article
- Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF.Frontiers in cardiovascular medicine · 2023Review
- Effects of voluntary running on the skeletal muscle of rats with pulmonary artery hypertension.Frontiers in physiology · 2023Article
- Near-infrared spectroscopy estimation of combined skeletal muscle oxidative capacity and OThe Journal of physiology · 2022Article
- Exercise intolerance in pulmonary arterial hypertension: insight into central and peripheral pathophysiological mechanisms.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- BN-PAGE-Based Approach to Study Thyroid Hormones and Mitochondrial Function.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Skeletal and Respiratory Muscle Dysfunctions in Pulmonary Arterial Hypertension.Journal of clinical medicine · 2020Review
- Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure.Journal of cachexia, sarcopenia and muscle · 2020Article
- Mitochondrial Dynamics in Rat Heart Induced by 5-Fluorouracil.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.American journal of respiratory and critical care medicine · 2017Article
- Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension.PloS one · 2017Article
- Dietary nitrate supplementation: impact on skeletal muscle vascular control in exercising rats with chronic heart failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women.European journal of applied physiology · 2016Article
- Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization.American journal of physiology. Heart and circulatory physiology · 2015Review
- Respiratory and limb muscle dysfunction in pulmonary arterial hypertension: a role for exercise training?Pulmonary circulation · 2015Review
- Rapid changes in NADH and flavin autofluorescence in rat cardiac trabeculae reveal large mitochondrial complex II reserve capacity.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Exercise intolerance is a cardinal symptom of right ventricular heart failure (RV HF) and skeletal muscle adaptations play a role in this limitation. We determined regional remodeling of muscle structure and mitochondrial function in a rat model of RV HF induced by monocrotaline injection (MCT; 60 mg·kg(-1); n = 11). Serial sections of the plantaris were stained for fiber type, succinate dehydrogenase (SDH) activity and capillaries. Mitochondrial function was assessed in permeabilized fibers using respirometry, and isolated complex activity by blue native gel electrophoresis (BN PAGE). All measurements were compared with saline-injected control animals (CON; n = 12). Overall fiber cross-sectional area was smaller in MCT than CON: 1,843 ± 114 vs. 2,322 ± 120 μm(2) (P = 0.009). Capillary-to-fiber ratio was lower in MCT in the oxidative plantaris region (1.65 ± 0.09 vs. 1.93 ± 0.07; P = 0.03), but not in the glycolytic region. SDH activity (P = 0.048) and maximal respiratory rate (P = 0.012) were each ∼15% lower in all fibers in MCT. ADP sensitivity was reduced in both skeletal muscle regions in MCT (P = 0.032), but normalized by rotenone. A 20% lower complex I/IV activity in MCT was confirmed by BN PAGE. MCT-treatment was associated with lower mitochondrial volume density (lower SDH activity), quality (lower complex I activity), and fewer capillaries per fiber area in oxidative skeletal muscle. These features are consistent with structural and functional remodeling of the determinants of oxygen supply potential and utilization that may contribute to exercise intolerance and reduced quality of life in patients with RV HF.
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Registered trials
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