ArticleThe EMBO journal2012
Coreceptor gene imprinting governs thymocyte lineage fate.
Article in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Unraveling CD8 lineage decisions reveals that functionally distinct CD8Nature immunology · 2026Article
- CD4, but not Cxcr6, is necessary for control of Pneumocystis murina infection.Microbes and infection · 2025Article
- Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus.Nature immunology · 2022Article
- An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.Immunity · 2020Article
- Constitutive CD8 expression drives innate CD8Life science alliance · 2020Article
- Requirement for intron structures in activating theProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Identification of lineage-specifying cytokines that signal all CD8Nature immunology · 2017Article
- Histone demethylases UTX and JMJD3 are required for NKT cell development in mice.Cell & bioscience · 2017Article
- Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.Immunology · 2016Article
- Specialized proteasome subunits have an essential role in the thymic selection of CD8(+) T cells.Nature immunology · 2016Article
- The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy.Cellular & molecular immunology · 2015Review
- A Tale from TGF-β Superfamily for Thymus Ontogeny and Function.Frontiers in immunology · 2015Review
- The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.Nature immunology · 2014Article
- A silencer-proximal intronic region is required for sustained CD4 expression in postselection thymocytes.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Transcriptional control of CD4 and CD8 coreceptor expression during T cell development.Cellular and molecular life sciences : CMLS · 2013Review
- Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus.The EMBO journal · 2013Article
- Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus.European journal of immunology · 2013Article
- Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus.The Journal of experimental medicine · 2012Article
- CD4-CD8 differentiation in the thymus: connecting circuits and building memories.Current opinion in immunology · 2012Review
- Coreceptor gene "imprinting:" a genetic solution to a developmental dilemma in T cells.Cell cycle (Georgetown, Tex.) · 2012Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
Immature thymocytes are bipotential cells that are signalled during positive selection to become either helper- or cytotoxic-lineage T cells. By tracking expression of lineage determining transcription factors during positive selection, we now report that the Cd8 coreceptor gene locus co-opts any coreceptor protein encoded within it to induce thymocytes to express the cytotoxic-lineage factor Runx3 and to adopt the cytotoxic-lineage fate, findings we refer to as 'coreceptor gene imprinting'. Specifically, encoding CD4 proteins in the endogenous Cd8 gene locus caused major histocompatibility complex class II-specific thymocytes to express Runx3 during positive selection and to differentiate into CD4(+) cytotoxic-lineage T cells. Our findings further indicate that coreceptor gene imprinting derives from the dynamic regulation of specific cis Cd8 gene enhancer elements by positive selection signals in the thymus. Thus, for coreceptor-dependent thymocytes, lineage fate is determined by Cd4 and Cd8 coreceptor gene loci and not by the specificity of T-cell antigen receptor/coreceptor signalling. This study identifies coreceptor gene imprinting as a critical determinant of lineage fate determination in the thymus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.