Evidence map›Paper›PMID 22036746›Full record

ReviewNature methods2011

Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy.

Jameson R Bothe, Evgenia N Nikolova, Catherine D Eichhorn, Jeetender Chugh, Alexandar L Hansen, Hashim M Al-Hashimi

Abstract readReview
In one paragraph

Review in Nature methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed.

  1. Article
  2. Folding and unfolding dynamics of a DNA aptamer studied by heteronuclearJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026
    Article
  3. Journal of molecular biology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Selective [9-Chembiochem : a European journal of chemical biology · 2025
    Article
  11. Investigating the Conformational Diversity of the TMR-3 Aptamer.Journal of the American Chemical Society · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Accurately Modeling RNA Stem-Loops in an Implicit Solvent Environment.Journal of chemical information and modeling · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jameson R BotheDepartment of Chemistry, The University of Michigan, Ann Arbor, Michigan, USA.
Evgenia N Nikolova
Catherine D Eichhorn
Jeetender Chugh
Alexandar L Hansen
Hashim M Al-Hashimi

Funding

Role of DNA structural dynamics in mutagenesis and oncogenesisR01GM089846 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Hashim M Al-Hashimi · 2010 to 2026
$5.2M
Targeting HIV-1 Regulatory RNA ElementsR01AI066975 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AL-HASHIMI, HASHIM M · 2005 to 2014
$2.6M
NIAID NIH HHS R01 AI066975NIGMS NIH HHS R01 GM089846
6 · The paper itself

Abstract

Many recently discovered noncoding RNAs do not fold into a single native conformation but sample many different conformations along their free-energy landscape to carry out their biological function. Here we review solution-state NMR techniques that measure the structural, kinetic and thermodynamic characteristics of RNA motions spanning picosecond to second timescales at atomic resolution, allowing unprecedented insights into the RNA dynamic structure landscape. From these studies a basic description of the RNA dynamic structure landscape is emerging, bringing new insights into how RNA structures change to carry out their function as well as applications in RNA-targeted drug discovery and RNA bioengineering.

Indexed as

KineticsNuclear Magnetic Resonance, BiomolecularRNAThermodynamicsRNA

Identifiers

PMID22036746
PMCPMC3320163

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.