ArticleNeuroImage2012
Magnetic susceptibility anisotropy of human brain in vivo and its molecular underpinnings.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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Who cites it
117 citing papers in PubMed, 214 citations in OpenAlex.
- DTI Tract-Based Quantitative Susceptibility Mapping: An Initial Feasibility Study to Investigate the Potential Role of Myelination in Brain Connectivity Change in Cerebral Palsy Patients During Autologous Cord Blood Cell Therapy Using a Rotationally-Invariant Quantitative Measure.Journal of magnetic resonance imaging : JMRI · 2021Trial
- Simulation of realistic brain phantoms for susceptibility tensor imaging.Magma (New York, N.Y.) · 2026Article
- Reducing Variability in Deep Gray Matter QSM Using Differential ROI Referencing: A Phantom and In Vivo Evaluation.NMR in biomedicine · 2026Article
- Field Strength-Dependent White Matter RMagnetic resonance in medicine · 2026Article
- Voxel-Wise Whole-Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review.Human brain mapping · 2026Review
- The role of low subcortical iron, white matter myelin, and oligodendrocytes in schizophrenia: a quantitative susceptibility mapping and diffusion tensor imaging study.Molecular psychiatry · 2026Article
- Observations of anisotropic paramagnetic and diamagnetic susceptibility in the primate brain.bioRxiv : the preprint server for biology · 2025Article
- Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer's disease pathology.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Quantitative susceptibility mapping in magnetically inhomogeneous tissues.Magnetic resonance in medicine · 2025Article
- Improving quantitative susceptibility mapping for the identification of traumatic brain injury neurodegeneration at the individual level.Zeitschrift fur medizinische Physik · 2025Article
- Predicting Mesoscopic Larmor Frequency Shifts in White Matter With Diffusion MRI-A Monte Carlo Study in Axonal Phantoms.NMR in biomedicine · 2025Article
- Susceptibility-induced internal gradients reveal axon morphology and cause anisotropic effects in the diffusion-weighted MRI signal.Scientific reports · 2024Article
- Diffusion tractography of kidney by high angular resolution diffusion imaging.Magnetic resonance letters · 2024Article
- Combined diffusion tensor imaging and quantitative susceptibility mapping to characterize normal-appearing white matter in self-limited epilepsy with centrotemporal spikes.Neuroradiology · 2024Article
- Direct comparison betweenNeuroImage · 2024Article
- Review
- High angular resolution susceptibility imaging and estimation of fiber orientation distribution functions in primate brain.NeuroImage · 2023Article
- Phase-shifted transverse relaxation orientation dependences in human brain white matter.NMR in biomedicine · 2023Article
- DeepSTI: Towards tensor reconstruction using fewer orientations in susceptibility tensor imaging.Medical image analysis · 2023Article
- Evaluation of multi-channel phase reconstruction methods for quantitative susceptibility mapping on postmortem human brain.Journal of magnetic resonance open · 2023Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Frequency shift of gradient-echo MRI provides valuable information for assessing brain tissues. Recent studies suggest that the frequency and susceptibility contrast depend on white matter fiber orientation. However, the molecular underpinning of the orientation dependence is unclear. In this study, we investigated the orientation dependence of susceptibility of human brain in vivo and mouse brains ex vivo. The source of susceptibility anisotropy in white matter is likely to be myelin as evidenced by the loss of anisotropy in the dysmyelinating shiverer mouse brain. A biophysical model is developed to investigate the effect of the molecular susceptibility anisotropy of myelin components, especially myelin lipids, on the bulk anisotropy observed by MRI. This model provides a consistent interpretation of the orientation dependence of macroscopic magnetic susceptibility in normal mouse brain ex vivo and human brain in vivo and the microscopic origin of anisotropic susceptibility. It is predicted by the theoretical model and illustrated by the experimental data that the magnetic susceptibility of the white matter is least diamagnetic along the fiber direction. This relationship allows an efficient extraction of fiber orientation using susceptibility tensor imaging. These results suggest that anisotropy on the molecular level can be observed on the macroscopic level when the molecules are aligned in a highly ordered manner. Similar to the utilization of magnetic susceptibility anisotropy in elucidating molecular structures, imaging magnetic susceptibility anisotropy may also provide a useful tool for elucidating the microstructure of ordered biological tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.