ArticleThe journal of pain2012
Excess risk of temporomandibular disorder associated with cigarette smoking in young adults.
Article in The journal of pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Tobacco smoking and its impact on pain intensity of temporomandibular disorders: A systematic review and metanalysis.Journal of oral rehabilitation · 2025Pooled it
- The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review.Journal of environmental and public health · 2018Pooled it
- The prevalence of smartphone, nicotine, and alcohol addiction among university students with temporomandibular disorders.BMC oral health · 2026Article
- Use of liquid platelet-rich fibrin (liquid PRF) in temporomandibular joint disorders: A narrative review with clinical recommendations.Periodontology 2000 · 2025Review
- Patterns of shared genetic risk between chronic pain, psychopathologies, and neuroticism.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Preliminary insights into the association between the well-being spectrum and temporomandibular disorders.Clinical oral investigations · 2025Article
- The Adaptive, Pain Sensitive, and Global Symptoms Clusters: Evidence from a Patient-Based Study.JDR clinical and translational research · 2024Article
- Temporomandibular Disorder Prevalence and Its Association with Lifestyle Habits in Biomedicine Students-A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
- Temporomandibular disorders in ankylosing spondylitis: a cross-sectional, monocentric study.Rheumatology international · 2020Observational
- Efficacy of the LED Red Light Therapy in the Treatment of Temporomandibular Disorders: Double Blind Randomized Controlled Trial.Pain research and treatment · 2019Article
- Chronic HPA axis response to stress in temporomandibular disorder.Journal of dental hygiene : JDH · 2014Article
- General health status and incidence of first-onset temporomandibular disorder: the OPPERA prospective cohort study.The journal of pain · 2013Observational
- Facial pain with localized and widespread manifestations: separate pathways of vulnerability.Pain · 2013Article
- Current smoking as a predictor of chronic musculoskeletal pain in young adult twins.The journal of pain · 2013Article
- Sleep apnea symptoms and risk of temporomandibular disorder: OPPERA cohort.Journal of dental research · 2013Article
- Chronic HPA axis response to stress in temporomandibular disorder.Journal of dental hygiene : JDH · 2013Article
- Role of allostatic load in sociodemographic patterns of pain prevalence in the U.S. population.The journal of pain · 2012Article
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- Effect of smoking status and nicotine dependence on pain intensity and outcome of treatment in Indian patients with temporomandibular disorders: A longitudinal cohort study.Journal of Indian Prosthodontic SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
unlabelledEvidence suggests that the effect of cigarette smoking on chronic pain is stronger in younger than older adults. This case-control study investigated whether age modified an effect of smoking on temporomandibular disorder (TMD) in 299 females aged 18 to 60 years. It also investigated the extent to which this relationship was explained by psychological profile, inflammatory response, and allergy. Cases were defined using the Research Diagnostic Criteria for Temporomandibular Disorders based on clinical examination. Psychological profile was evaluated using standardized instruments. Inflammatory response was evaluated with 11 cytokines isolated in plasma. History of allergy conditions was self-reported. Odds ratios (ORs) for the effect of smoking were calculated using binary logistic regression. Stratified analyses and the likelihood ratio test examined effect modification by smoking. Compared with nonsmokers, ever smokers aged <30 years had higher odds of TMD (OR = 4.14, 95% CI: 1.57, 11.35) than older adults (OR = 1.23, 95% CI: .55, 2.78) (P (effect modification) = .038). Adjustment for psychological profile, cytokines, and history of allergy-like conditions attenuated the effect by 45% to statistical nonsignificance. The main finding was reproduced with secondary analyses of 2 nationally representative surveys of adults conducted in the US and Australia. PERSPECTIVE: This study showed that smoking was associated with TMD risk in females, but only in young adulthood. It replicated this finding in 2 nationally representative surveys of females in the US and Australia. Findings may alert clinicians to recognize that smoking is a concern for TMD in younger female patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.