ArticleCurrent biology : CB2011
A pathway for synapsis initiation during zygotene in Drosophila oocytes.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65 citing papers in PubMed, 101 citations in OpenAlex.
- Ataxin-2 regulates the synaptonemal complex to ensure chromosome pairing during female meiosis.Genetics · 2026Article
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- Meiotic pairing through barcode-like satellite DNA repeats.Nature communications · 2026Article
- Structure and function of the synaptonemal complex.The Journal of cell biology · 2026Review
- The Drosophila mauritiana synaptonemal complex protein C(3)G repatterns the recombination landscape of Drosophila melanogaster.PLoS genetics · 2025Article
- The deubiquitinase Usp7 inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Analysis of meiotic recombination in Drosophila simulans shows no evidence of an interchromosomal effect.Genetics · 2024Article
- Chromosome segregation during spermatogenesis occurs through a unique center-kinetic mechanism in holocentric moth species.PLoS genetics · 2024Article
- Uncharted territories: Solving the mysteries of male meiosis in flies.PLoS genetics · 2024Review
- A dynamic population of prophase CENP-C is required for meiotic chromosome segregation.PLoS genetics · 2023Article
- Building the synaptonemal complex: Molecular interactions between the axis and the central region.PLoS genetics · 2023Review
- Kinetic analysis of synaptonemal complex dynamics during meiosis of yeastFrontiers in cell and developmental biology · 2023Article
- Premeiotic pairing of homologous chromosomes duringProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- Oo-site: A dashboard to visualize gene expression during Drosophila oogenesis suggests meiotic entry is regulated post-transcriptionally.Biology open · 2022Article
- A Brief History ofGenes · 2022Review
- Meiosis in crops: from genes to genomes.Journal of experimental botany · 2021Review
- Review
- Evolution, Expression and Meiotic Behavior of Genes Involved in Chromosome Segregation of Monotremes.Genes · 2021Article
- Distal Bias of Meiotic Crossovers in Hexaploid Bread Wheat Reflects Spatio-Temporal Asymmetry of the Meiotic Program.Frontiers in plant science · 2021Article
5 more citing papers are in PubMed but not listed here.
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4 authors at 1 institution in 1 country.
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Abstract
Formation of the synaptonemal complex (SC), or synapsis, between homologs in meiosis is essential for crossing over and chromosome segregation [1-4]. How SC assembly initiates is poorly understood but may have a critical role in ensuring synapsis between homologs and regulating double-strand break (DSB) and crossover formation. We investigated the genetic requirements for synapsis in Drosophila and found that there are three temporally and genetically distinct stages of synapsis initiation. In "early zygotene" oocytes, synapsis is only observed at the centromeres. We also found that nonhomologous centromeres are clustered during this process. In "mid-zygotene" oocytes, SC initiates at several euchromatic sites. The centromeric and first euchromatic SC initiation sites depend on the cohesion protein ORD. In "late zygotene" oocytes, SC initiates at many more sites that depend on the Kleisin-like protein C(2)M. Surprisingly, late zygotene synapsis initiation events are independent of the earlier mid-zygotene events, whereas both mid and late synapsis initiation events depend on the cohesin subunits SMC1 and SMC3. We propose that the enrichment of cohesion proteins at specific sites promotes homolog interactions and the initiation of euchromatic SC assembly independent of DSBs. Furthermore, the early euchromatic SC initiation events at mid-zygotene may be required for DSBs to be repaired as crossovers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.