ReviewThe Journal of allergy and clinical immunology2011
New insights into the natural history of asthma: primary prevention on the horizon.
Review in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02148796 (Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy, Safety and Tolerability of ORal Bacterial EXtract for the Prevention of Wheezing Lower Respiratory Tract Illness), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy, Safety and Tolerability of ORal Bacterial EXtract for the Prevention of Wheezing Lower Respiratory Tract Illness (ORBEX)
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Psychosocial factors and behavioral medicine interventions in asthma.Journal of consulting and clinical psychology · 2013Pooled it
- Children with poorly controlled asthma: Randomized controlled trial of a home-based environmental control intervention.Pediatric pulmonology · 2019Trial
- Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies.Frontiers in immunology · 2024Review
- Patterns in the Development of Pediatric Allergy.Pediatrics · 2023Article
- Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1-allergic asthma.Frontiers in allergy · 2023Review
- Protective Effects of Korean Herbal Remedy against Airway Inflammation in an Allergic Asthma by Suppressing Eosinophil Recruitment and Infiltration in Lung.Antioxidants (Basel, Switzerland) · 2020Article
- Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model.Human vaccines & immunotherapeutics · 2020Article
- Article
- Probiotics, prebiotics, and synbiotics for the treatment of asthma: Protocol for a systematic review.Medicine · 2019Article
- Early Origins of Asthma. Role of Microbial Dysbiosis and Metabolic Dysfunction.American journal of respiratory and critical care medicine · 2018Review
- Does raising awareness in families reduce environmental tobacco smoke exposure in wheezy children?Postepy dermatologii i alergologii · 2017Article
- Better understanding of childhood asthma, towards primary prevention - are we there yet? Consideration of pertinent literature.F1000Research · 2017Review
- Changing Trends in Asthma Prevalence Among Children.Pediatrics · 2016Article
- Pathogenetic and prognostic roles of bloodborne fibrocytes in asthma.Journal of Zhejiang University. Science. B · 2015Review
- Risk factors associated with asthma, atopic dermatitis and rhinoconjunctivitis in a rural Senegalese cohort.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2015Article
- Ovalbumin sensitization of guinea pig at birth prevents the ontogenetic decrease in airway smooth muscle responsiveness.Physiological reports · 2014Article
- The human microbiome. Early life determinant of health outcomes.Annals of the American Thoracic Society · 2014Article
- Is asthma an infectious disease? New evidence.Current allergy and asthma reports · 2013Review
- Asthma.Lancet (London, England) · 2013Review
- Research needs in allergy: an EAACI position paper, in collaboration with EFA.Clinical and translational allergy · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recent studies of the natural history of asthma have shifted attention toward viral respiratory tract illness in early life as a major risk factor associated with the development of the most persistent forms of the disease. Although early aeroallergen sensitization is strongly associated with chronic asthma, several trials in which single-aeroallergen exposure in pregnancy and early childhood was successfully accomplished and compared with sham avoidance have failed to show any decrease in asthma incidence. New evidence suggests that complex interactions occur between viral infection and aeroallergen sensitization in genetically susceptible subjects that trigger the immune responses and airway changes that are characteristic of persistent asthma. The finding that exposure to bacterial products among children raised on farms is associated with diminished asthma prevalence during the school years has now been replicated, and experimental studies have suggested that these effects are mediated by the activation of regulatory T cells in the airway. It is thus plausible to hypothesize that primary prevention of asthma could be attained through surrogate therapeutic interventions that activate similar mechanisms in young children at high risk for asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.