ReviewFertility and sterility2011
Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies?
Review in Fertility and sterility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Calcium signals shape metabolic control of H3K27ac and H3K18la to regulate EGA.bioRxiv : the preprint server for biology · 2025Article
- Article
- Assessing the impact of medically assisted reproduction on autism spectrum disorder risk.Journal of assisted reproduction and genetics · 2024Article
- Effects of assisted reproductive technology on gene expression in heart and spleen tissues of adult offspring mouse.Frontiers in endocrinology · 2023Article
- Conception by fertility treatment and offspring deoxyribonucleic acid methylation.Fertility and sterility · 2021Article
- The effect of blastomere loss during frozen embryo transfer on the transcriptome of offspring's umbilical cord blood.Molecular biology reports · 2020Article
- Multifactorial analysis of the stochastic epigenetic variability in cord blood confirmed an impact of common behavioral and environmental factors but not of in vitro conception.Clinical epigenetics · 2018Article
- Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.EBioMedicine · 2017Article
- A Molecular Perspective on Procedures and Outcomes with Assisted Reproductive Technologies.Cold Spring Harbor perspectives in medicine · 2016Review
- Differences in infant feeding practices by mode of conception in a United States cohort.Fertility and sterility · 2016Article
- Deoxyribonucleic acid methylation profiling of single human blastocysts by methylated CpG-island amplification coupled with CpG-island microarray.Fertility and sterility · 2015Article
- In vitro fertilization affects growth and glucose metabolism in a sex-specific manner in an outbred mouse model.Biology of reproduction · 2014Article
- ART and health: clinical outcomes and insights on molecular mechanisms from rodent studies.Molecular human reproduction · 2013Review
- Preimplantation stress and development.Birth defects research. Part C, Embryo today : reviews · 2012Review
- The presence, role and clinical use of spermatozoal RNAs.Human reproduction updateReview
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo review recent data regarding subtle, but widespread, epigenetic alterations in phenotypically normal offspring conceived by assisted reproductive technologies (ART) compared with offspring conceived in vivo.
designA PubMed computer search was performed to identify relevant articles.
settingResearch institution. PATIENT(S): Not applicable. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Not applicable. RESULT(S): Studies in animals indicate that in vitro culture may be associated with widespread alterations in imprinted genes compared with in vivo-conceived offspring. Recently, studies in humans have likewise demonstrated widespread changes in DNA methylation, including genes linked to adipocyte development, insulin signaling, and obesity in offspring conceived by ART compared with in vivo-conceived children. Changes in multiple imprinted genes after ART also were noted in additional studies, which suggested that the diagnosis of infertility may explain the differences between in vivo-conceived and ART offspring. CONCLUSION(S): These data suggest that ART is associated with widespread epigenetic modifications in phenotypically normal children, and that these modifications may increase the risk of adverse cardiometabolic outcomes. Further research is needed to elucidate the possible relationship between ART, genome-wide alterations in imprinted genes, and their potential relevance to subtle cardiometabolic consequences reported in ART offspring.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.