Evidence map›Paper›PMID 22035866›Full record

ReviewJournal of genetics and genomics = Yi chuan xue bao2011

Extra sex combs, chromatin, and cancer: exploring epigenetic regulation and tumorigenesis in Drosophila.

Can Zhang, Bo Liu, Guangyao Li, Lei Zhou

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of genetics and genomics = Yi chuan xue bao, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Wisdom from the fly.Trends in genetics : TIG · 2014
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Can ZhangDepartment of Molecular Genetics & Microbiology, Shands Cancer Center, University of Florida, Gainesville, USA.
Bo Liu
Guangyao Li
Lei Zhou
University of Florida Health · US

Funding

Probing Complexity of UV Induced Apoptosis in DrosophilaR01CA095542 · NCI · UNIVERSITY OF FLORIDA · PI ZHOU, LEI · 2003 to 2007
$1.2M
Rapid Induction of apoptosis against viral infectionR01GM106174 · NIGMS · UNIVERSITY OF FLORIDA · PI ZHOU, LEI · 2014 to 2017
$1.1M
Systematic analysis of cell death regulation in mosquitoesR56AI079074 · NIAID · UNIVERSITY OF FLORIDA · PI ZHOU, LEI · 2008 to 2009
$652k
NCI NIH HHS CA095542NCI NIH HHS R01 CA095542NIAID NIH HHS AI079074NIAID NIH HHS R56 AI079074NIGMS NIH HHS R01 GM106174
6 · The paper itself

Abstract

Developmental genetic studies in Drosophila unraveled the importance of Polycomb group (PcG) and Trithorax group (TrxG) genes in controlling cellular identity. PcG and TrxG proteins form histone modifying complexes that catalyze repressive or activating histone modifications, respectively, and thus maintaining the expression status of homeotic genes. Human orthologs of PcG and TrxG genes are implicated in tumorigenesis as well as in determining the prognosis of individual cancers. Recent whole genome analyses of cancers also highlighted the importance of histone modifying proteins in controlling tumorigenesis. Comprehensive understanding of the mechanistic relationship between histone regulation and tumorigenesis holds the promise of significantly advancing our understanding and management of cancer. It is anticipated that Drosophila melanogaster, the model organism that contributed significantly to our understanding of the functional role of histone regulation in development, could also provide unique insight for our understanding of how histone dysregulation can lead to cancer. In this review, we will discuss several recent advances in this regard.

Indexed as

AnimalsCell Transformation, NeoplasticChromatinChromosomal Proteins, Non-HistoneDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsEpigenesis, GeneticGene Expression Regulation, NeoplasticHistonesHumansNeoplasmsPolycomb Repressive Complex 1ChromatinChromosomal Proteins, Non-HistoneDrosophila ProteinsHistonesPc protein, DrosophilaPolycomb Repressive Complex 1trx protein, Drosophila

Identifiers

PMID22035866
PMCPMC5291746
OpenAlexW2000823353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.