ArticleChemistry & biology2011
Compound prioritization methods increase rates of chemical probe discovery in model organisms.
Article in Chemistry & biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Chemical Inhibition of Sterol Biosynthesis.Biomolecules · 2024Pooled it
- Drug screens using the nematode Caenorhabditis elegans.Genetics · 2025Review
- The small molecule Zaractin activates ZAR1-mediated immunity inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Compound Prioritization through Meta-Analysis Enhances the Discovery of Antimicrobial Hits against Bacterial Pathogens.Antibiotics (Basel, Switzerland) · 2021Article
- Emerging prospects of macro- and microalgae as prebiotic.Microbial cell factories · 2021Review
- Small Molecule Adjuvants Potentiate Colistin Activity and Attenuate Resistance Development inInfection and drug resistance · 2020Article
- Novel small molecules affecting cell membrane as potential therapeutics for avian pathogenic Escherichia coli.Scientific reports · 2018Article
- Novel Imidazole and Methoxybenzylamine Growth Inhibitors Affecting Salmonella Cell Envelope Integrity and its Persistence in Chickens.Scientific reports · 2018Article
- Novel small molecule modulators of quorum sensing in avian pathogenic Escherichia coli (APEC).Virulence · 2018Article
- Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.PLoS neglected tropical diseases · 2016Article
- Small-molecule antagonists of germination of the parasitic plant Striga hermonthica.Nature chemical biology · 2016Article
- Novel Anti-Campylobacter Compounds Identified Using High Throughput Screening of a Pre-selected Enriched Small Molecules Library.Frontiers in microbiology · 2016Article
- Functional genomics to uncover drug mechanism of action.Nature chemical biology · 2015Review
- The re-emergence of natural products for drug discovery in the genomics era.Nature reviews. Drug discovery · 2015Review
- Discovery of novel small molecule modulators of Clavibacter michiganensis subsp. michiganensis.Frontiers in microbiology · 2015Article
- SwissTargetPrediction: a web server for target prediction of bioactive small molecules.Nucleic acids research · 2014Article
- Mapping the cellular response to small molecules using chemogenomic fitness signatures.Science (New York, N.Y.) · 2014Article
- Composition and applications of focus libraries to phenotypic assays.Frontiers in pharmacology · 2014Review
- Systems-level antimicrobial drug and drug synergy discovery.Nature chemical biology · 2013Article
- A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis.Genome biology · 2012Article
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
Preselection of compounds that are more likely to induce a phenotype can increase the efficiency and reduce the costs for model organism screening. To identify such molecules, we screened ~81,000 compounds in Saccharomyces cerevisiae and identified ~7500 that inhibit cell growth. Screening these growth-inhibitory molecules across a diverse panel of model organisms resulted in an increased phenotypic hit-rate. These data were used to build a model to predict compounds that inhibit yeast growth. Empirical and in silico application of the model enriched the discovery of bioactive compounds in diverse model organisms. To demonstrate the potential of these molecules as lead chemical probes, we used chemogenomic profiling in yeast and identified specific inhibitors of lanosterol synthase and of stearoyl-CoA 9-desaturase. As community resources, the ~7500 growth-inhibitory molecules have been made commercially available and the computational model and filter used are provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.