ArticleChemistry & biology2011
Identification of a eukaryotic reductive dechlorinase and characterization of its mechanism of action on its natural substrate.
Article in Chemistry & biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Misregulation of bromotyrosine compromises fertility in maleProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Generating polyketide diversity inProceedings. Biological sciences · 2022Article
- Loss of the Polyketide Synthase StlB Results in Stalk Cell Overproduction in Polysphondylium violaceum.Genome biology and evolution · 2020Article
- Microbial Synthesis and Transformation of Inorganic and Organic Chlorine Compounds.Frontiers in microbiology · 2018Review
- Glutathione S-transferase 4 is a putative DIF-binding protein that regulates the size of fruiting bodies inBiochemistry and biophysics reports · 2016Article
- A switch between one- and two-electron chemistry of the human flavoprotein iodotyrosine deiodinase is controlled by substrate.The Journal of biological chemistry · 2015Article
- Cell signaling during development of Dictyostelium.Developmental biology · 2014Review
- Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere.PLoS biology · 2014Article
- Highlighting a π-π interaction: a protein modeling and molecular dynamics simulation study on Anopheles gambiae glutathione S-transferase 1-2.Journal of molecular modeling · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Chlorinated compounds are important environmental pollutants whose biodegradation may be limited by inefficient dechlorinating enzymes. Dictyostelium amoebae produce a chlorinated alkyl phenone called DIF which induces stalk cell differentiation during their multicellular development. Here we describe the identification of DIF dechlorinase. DIF dechlorinase is active when expressed in bacteria, and activity is lost from Dictyostelium cells when its gene, drcA, is knocked out. It has a K(m) for DIF of 88 nM and K(cat) of 6.7 s(-1). DrcA is related to glutathione S-transferases, but with a key asparagine-to-cysteine substitution in the catalytic pocket. When this change is reversed, the enzyme reverts to a glutathione S-transferase, thus suggesting a catalytic mechanism. DrcA offers new possibilities for the rational design of bioremediation strategies.
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Registered trials
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