ArticleChemistry & biology2011
Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase.
Article in Chemistry & biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Unveiling the molecular mechanisms of the type IX secretion system's response regulator: Structural and functional insights.PNAS nexus · 2024Article
- Structure-function analysis of PorXScientific reports · 2024Article
- Purification, crystallization and crystallographic analysis of the PorX response regulator associated with the type IX secretion system.Acta crystallographica. Section F, Structural biology communications · 2022Article
- Global and seasonal variation of marine phosphonate metabolism.The ISME journal · 2022Article
- Strategies of organic phosphorus recycling by soil bacteria: acquisition, metabolism, and regulation.Environmental microbiology reports · 2022Review
- Article
- Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions.International journal of molecular sciences · 2021Review
- c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genome Insights of the Plant-Growth Promoting BacteriumFrontiers in microbiology · 2020Article
- Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium.Journal of molecular biology · 2018Article
- Recent Developments in Organophosphorus Flame Retardants Containing P-C Bond and Their Applications.Materials (Basel, Switzerland) · 2017Review
- Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.Chemical reviews · 2017Review
- Article
- Draft Genome Sequence of Serratia sp. Strain DD3, Isolated from the Guts of Daphnia magna.Genome announcements · 2014Article
- Utilization of glyphosate as phosphate source: biochemistry and genetics of bacterial carbon-phosphorus lyase.Microbiology and molecular biology reviews : MMBR · 2014Review
- Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation.Chemistry & biology · 2014Article
- A microfluidic approach for protein structure determination at room temperature via on-chip anomalous diffraction.Lab on a chip · 2013Article
- Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology.Current opinion in chemical biology · 2013Review
- Organophosphonates revealed: new insights into the microbial metabolism of ancient molecules.Nature reviews. Microbiology · 2013Review
- Answers to the carbon-phosphorus lyase conundrum.Chembiochem : a European journal of chemical biology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bacteria have evolved pathways to metabolize phosphonates as a nutrient source for phosphorus. In Sinorhizobium meliloti 1021, 2-aminoethylphosphonate is catabolized to phosphonoacetate, which is converted to acetate and inorganic phosphate by phosphonoacetate hydrolase (PhnA). Here we present detailed biochemical and structural characterization of PhnA that provides insights into the mechanism of C-P bond cleavage. The 1.35 Å resolution crystal structure reveals a catalytic core similar to those of alkaline phosphatases and nucleotide pyrophosphatases but with notable differences, such as a longer metal-metal distance. Detailed structure-guided analysis of active site residues and four additional cocrystal structures with phosphonoacetate substrate, acetate, phosphonoformate inhibitor, and a covalently bound transition state mimic provide insight into active site features that may facilitate cleavage of the C-P bond. These studies expand upon the array of reactions that can be catalyzed by enzymes of the alkaline phosphatase superfamily.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.