ArticleJournal of cardiovascular electrophysiology2012
Heart failure decreases nerve activity in the right atrial ganglionated plexus.
Article in Journal of cardiovascular electrophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control.AIChE journal. American Institute of Chemical Engineers · 2023Article
- Redistribution of adipose tissue is associated with left atrial remodeling and dysfunction in patients with atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- Recording Intrinsic Nerve Activity at the Sinoatrial Node in Normal Dogs With High-Density Mapping.Circulation. Arrhythmia and electrophysiology · 2021Article
- Translational neurocardiology: preclinical models and cardioneural integrative aspects.The Journal of physiology · 2016Review
- Association of epicardial and peri-atrial adiposity with the presence and severity of non-valvular atrial fibrillation.The international journal of cardiovascular imaging · 2015Article
- Effects of carvedilol on cardiac autonomic nerve activities during sinus rhythm and atrial fibrillation in ambulatory dogs.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2014Article
- Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy.Circulation research · 2014Review
- Autonomic nerve activity and blood pressure in ambulatory dogs.Heart rhythm · 2014Article
- Therapeutic potential of Pnmt+ primer cells for neuro/myocardial regeneration.American journal of stem cells · 2013Review
- Network interactions within the canine intrinsic cardiac nervous system: implications for reflex control of regional cardiac function.The Journal of physiology · 2013Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveWe tested the hypothesis that heart failure (HF) results in right atrial ganglionated plexus (RAGP) denervation that contributes to sinoatrial node dysfunction.
backgroundHF is associated with sinoatrial node dysfunction. However, the detailed mechanisms remain unclear.
methodsWe recorded nerve activity (NA) from the RAGP, right stellate ganglion (SG), and right vagal nerve in 7 ambulatory dogs at baseline and after pacing-induced HF. We also determined the effects of RAGP stimulation in isolated normal and HF canine RA.
resultsNAs in both the SG and vagal were significantly higher in HF than at baseline. The relationship between 1-minute integrated NAs of vagal and RAGP showed either a positive linear correlation (Group 1, n = 4) or an L-shaped correlation (Group 2, n = 3). In all dogs, a reduced heart rate was observed when vagal-NA was associated with simultaneously increased RAGP-NA. On the other hand, when vagal-NA was not associated with increased RAGP-NA, the heart rate was not reduced. The induction of HF significantly decreased RAGP-NA in all dogs (P < 0.05). Stimulating the superior RAGP in isolated RA significantly reduced the sinus rate in normal but not the HF hearts. Immunohistochemical staining revealed lower densities of tyrosine hydroxylase- and choline acetyltransferase-positive nerve tissues in HF RAGP than normal (P < 0.001 and P = 0.001, respectively).
conclusionsThe RAGP-NA is essential for the vagal nerve to counterbalance the SG in sinus rate control. In HF, RAGP denervation and decreased RAGP-NA contribute to the sinus node dysfunction.
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