ReviewAntioxidants & redox signaling2012
In utero oxidative stress epigenetically programs antioxidant defense capacity and adulthood diseases.
Review in Antioxidants & redox signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Redox Imbalance in Gestational Diabetes Mellitus: Mechanistic Insights, Emerging Biomarkers, and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Effects of different maternal diets on adipose tissue inflammation and liver tissue oxidative stress in dams and their female offspring.Molecular and cellular biochemistry · 2024Article
- Pyometra alters the redox status and expression of estrogen and progesterone receptors in the uterus of domestic cats.Journal of feline medicine and surgery · 2023Article
- Oxidative Stress in Assisted Reproductive Techniques, with a Focus on an Underestimated Risk Factor.Current issues in molecular biology · 2023Review
- Maternal heme-enriched diet promotes a gut pro-oxidative status associated with microbiota alteration, gut leakiness and glucose intolerance in mice offspring.Redox biology · 2022Article
- Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy.Antioxidants (Basel, Switzerland) · 2022Review
- The Long-Term Effects of Developmental Hypoxia on Cardiac Mitochondrial Function in Snapping Turtles.Frontiers in physiology · 2021Article
- Phthalate Exposure and Long-Term Epigenomic Consequences: A Review.Frontiers in genetics · 2020Review
- Sex-Specificity of Oxidative Stress in Newborns Leading to a Personalized Antioxidant Nutritive Strategy.Antioxidants (Basel, Switzerland) · 2018Review
- The postpartum effect of maternal diabetes on the circulating levels of sirtuins and superoxide dismutase.FEBS open bio · 2018Article
- Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors.Advances in nutrition (Bethesda, Md.) · 2017Review
- Sex dimorphism in late gestational sleep fragmentation and metabolic dysfunction in offspring mice.Sleep · 2015Article
- Maternal obesity and overnutrition increase oxidative stress in male rat offspring reproductive system and decrease fertility.International journal of obesity (2005) · 2015Article
- Transcriptional regulation of programmed hypertension by melatonin: an epigenetic perspective.International journal of molecular sciences · 2014Review
- A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events.Hepatic medicine : evidence and research · 2014Review
- Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus.The Journal of clinical endocrinology and metabolism · 2013Article
- Role of the hypothalamic-pituitary-adrenal axis in developmental programming of health and disease.Frontiers in neuroendocrinology · 2013Review
- Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
significanceMaternal health and diet during gestation are critical for predicting fetal outcomes, both immediately at birth and in adulthood. While epigenetic modifications have previously been tightly linked to carcinogenesis, recent advances in the field have suggested that numerous adulthood diseases, including those characteristic of metabolic syndrome, could be programmed in utero in response to maternal exposures, and these "programmable" diseases are associated with epigenetic modifications of vital genes. RECENT ADVANCES: While little is currently known about the epigenetic regulation of the antioxidant (AOX) defense system, several studies in animals show that AOX defense capacity may be programmed in utero, making it likely that the critical genes involved in this pathway are epigenetically regulated, either by DNA methylation or by the modification of histone tails. CRITICAL ISSUES: This article presents the most current knowledge of the in utero regulation of the AOX defense capacity, and will specifically focus on the potential epigenetic regulation of this system in response to various in utero exposures or stimuli. The ability to appropriately respond to oxidative stress is critical for the health and survival of any organism, and the potential programming of this capacity may provide a link between the in utero environment and the tendency of certain individuals to be more susceptible toward disease stimuli in their postnatal environments. FUTURE DIRECTIONS: We sincerely hope that future studies which result in a deeper understanding of the in utero programming of the epigenome will lead to novel and effective therapies for the treatment of epigenetically linked diseases.
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