ArticleBMC musculoskeletal disorders2011
Non-invasive muscle contraction assay to study rodent models of sarcopenia.
Article in BMC musculoskeletal disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- CORP: In vivo muscle strength-perspectives on the design and interpretation of preclinical animal studies.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Review
- Puerarin Delays the Progression of Muscle Atrophy in Mice With Dexamethasone-Induced Sarcopenia Through Inhibiting the TNF-α/NF-κB Pathway.Food science & nutrition · 2025Article
- Single-cell RNA-seq reveals interferon-induced guanylate-binding proteins are linked with sarcopenia.Journal of cachexia, sarcopenia and muscle · 2022Article
- Development and Verification of a Combined Diagnostic Model for Sarcopenia with Random Forest and Artificial Neural Network.Computational and mathematical methods in medicine · 2022Article
- The oestrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss.Experimental physiology · 2021Article
- Mouse models of sarcopenia: classification and evaluation.Journal of cachexia, sarcopenia and muscle · 2021Review
- In vivo Measurement of Knee Extensor Muscle Function in Mice.Journal of visualized experiments : JoVE · 2021Article
- Effects of the Combination of β-Hydroxy-β-Methyl Butyrate and R(+) Lipoic Acid in a Cellular Model of Sarcopenia.Molecules (Basel, Switzerland) · 2020Article
- Laryngeal muscle biology in theJournal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Changes in Body Composition of Old Rats at Different Time Points After Dexamethasone Administration.Current aging science · 2019Article
- Identifying and Implementing Endpoints for Geriatric Mice.Comparative medicine · 2018Article
- 3D Bioprinted Human Skeletal Muscle Constructs for Muscle Function Restoration.Scientific reports · 2018Article
- Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair.Journal of visualized experiments : JoVE · 2016Article
- Article
- A standardized rat model of volumetric muscle loss injury for the development of tissue engineering therapies.BioResearch open access · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAge-related sarcopenia is a disease state of loss of muscle mass and strength that affects physical function and mobility leading to falls, fractures, and disability. The need for therapies to treat age-related sarcopenia has attracted intensive preclinical research. To facilitate the discovery of these therapies, we have developed a non-invasive rat muscle functional assay system to efficiently measure muscle force and evaluate the efficacy of drug candidates.
methodsThe lower leg muscles of anesthetized rats are artificially stimulated with surface electrodes on the knee holders and the heel support, causing the lower leg muscles to push isometric pedals that are attached to force transducers. We developed a stimulation protocol to perform a fatigability test that reveals functional muscle parameters like maximal force, the rate of fatigue, fatigue-resistant force, as well as a fatigable muscle force index. The system is evaluated in a rat aging model and a rat glucocorticoid-induced muscle loss model
resultsThe aged rats were generally weaker than adult rats and showed a greater reduction in their fatigable force when compared to their fatigue-resistant force. Glucocorticoid treated rats mostly lost fatigable force and fatigued at a higher rate, indicating reduced force from glycolytic fibers with reduced energy reserves.
conclusionsThe involuntary contraction assay is a reliable system to assess muscle function in rodents and can be applied in preclinical research, including age-related sarcopenia and other myopathy.
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