Evidence map›Paper›PMID 22034969›Full record

SynthesisBMC musculoskeletal disorders2011

Systematic review with meta-analysis: cytokines in fibromyalgia syndrome.

Nurcan Uçeyler, Winfried Häuser, Claudia Sommer

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC musculoskeletal disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04007705 (Effects of an Anti-inflammatory Nutritional Intervention in Disease Assessment Parameters, Inflammatory Markers, and Quality of Life of Patients With Fibromyalgia), which is not on this map. Cited by 129 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 10 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04007705 nacompletednot on this mapstarted 2019, after this paper: background citation

Effects of an Anti-inflammatory Nutritional Intervention in Disease Assessment Parameters, Inflammatory Markers, and Quality of Life of Patients With Fibromyalgia

TypeinterventionalSponsorUniversidade do PortoRan2019 to 2020Enrolled46ConditionsFibromyalgiaArmsAnti-inflammatory and low FODMAPs diet, General healthy eating
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 10 syntheses or guidelines pooled it, 247 citations in OpenAlex.

  1. Pooled it
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  6. Mirtazapine for fibromyalgia in adults.The Cochrane database of systematic reviews · 2018
    Pooled it
  7. Cannabinoids for fibromyalgia.The Cochrane database of systematic reviews · 2016
    Pooled it
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  9. Guideline
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nurcan UçeylerDepartment of Neurology, University of Würzburg, Josef-Schneider-Str, 11, 97080 Würzburg, Germany. ueceyler_n@klinik.uni-wuerzburg.de
Winfried Häuser
Claudia Sommer
University of Würzburg · DEKlinikum Saarbrücken · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo perform a systematic review and meta-analysis on cytokine levels in patients with fibromyalgia syndrome (FMS).

methodsThrough December 2010 we systematically reviewed the databases PubMed, MEDLINE, and PsycINFO and screened the reference lists of 22 review articles for suitable original articles. Original articles investigating cytokines in patients with FMS were included. Data were extracted by two independent authors. Differences of the cytokine levels of FMS patients and controls were summarized by standardized mean differences (SMD) using a random effects model. Study quality was assessed applying methodological scores: modified Center of Evidence Based Medicine, Newcastle-Ottawa-Scale, and Würzburg Methodological Quality Score.

resultsTwenty-five articles were included investigating 1255 FMS patients and 800 healthy controls. Data of 13/25 studies entered meta-analysis. The overall methodological quality of studies was low. The results of the majority of studies were not comparable because methods, investigated material, and investigated target cytokines differed. Systematic review of the selected 25 articles revealed that FMS patients had higher serum levels of interleukin (IL)-1 receptor antagonist, IL-6, and IL-8, and higher plasma levels of IL-8. Meta-analysis of eligible studies showed that FMS patients had higher plasma IL-6 levels compared to controls (SMD = -0.34 [-0.64, -0.03] 95% CI; p = 0.03). The majority of investigated cytokines were not different between patients and controls.

conclusionsThe pathophysiological role of cytokines in FMS is still unclear. Studies of higher quality and with higher numbers of subjects are needed.

Indexed as

CytokinesFibromyalgiaHumansModels, ImmunologicalRandom AllocationCytokines

Identifiers

PMID22034969
PMCPMC3234198
OpenAlexW2156452823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.