ArticleThe European respiratory journal2012
The resistive and elastic work of breathing during exercise in patients with chronic heart failure.
Article in The European respiratory journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Sex differences in the work of breathing during exercise are independent of forced vital capacity in healthy adults.Experimental physiology · 2025Article
- Differences of ventilatory muscle recruitment and work of breathing in COPD and interstitial lung disease: clarifications.ERJ open research · 2025Article
- Work of Breathing: Physiology, Measurement, and Diagnostic Value in Childhood Pneumonia.Children (Basel, Switzerland) · 2024Review
- [Exploratory study on quantitative analysis of nocturnal breathing patterns in patients with acute heart failure based on wearable devices].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
- Observational
- Consequences of group III/IV afferent feedback and respiratory muscle work on exercise tolerance in heart failure with reduced ejection fraction.Experimental physiology · 2023Review
- Higher Work of Breathing During Exercise in Heart Failure With Preserved Ejection Fraction.Chest · 2023Article
- Effects of comorbid type II diabetes mellitus and heart failure on rat hindlimb and respiratory muscle blood flow during treadmill exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Physiologic function of mediastinum space.Annals of medicine and surgery (2012) · 2022Review
- Exercise training decreases intercostal and transversus abdominis muscle blood flows in heart failure rats during submaximal exercise.Respiratory physiology & neurobiology · 2021Article
- Article
- Relationship between Driving Pressure and Mortality in Ventilated Patients with Heart Failure: A Cohort Study.Canadian respiratory journal · 2021Article
- Respiratory muscle work influences locomotor convective and diffusive oxygen transport in human heart failure during exercise.Physiological reports · 2020Article
- Exercise Intolerance in Heart Failure: Central Role for the Pulmonary System.Exercise and sport sciences reviews · 2020Review
- Ventilatory constraints influence physiological dead space in heart failure.Experimental physiology · 2019Article
- Sex differences in large conducting airway anatomy.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Resistive and elastic work of breathing in older and younger adults during exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Assessment of Thoracic Blood Volume by Computerized Tomography in Patients With Heart Failure and Periodic Breathing.Journal of cardiac failure · 2018Article
- The influence of thoracic gas compression and airflow density dependence on the assessment of pulmonary function at high altitude.Physiological reports · 2018Article
- Dietary nitrate supplementation opposes the elevated diaphragm blood flow in chronic heart failure during submaximal exercise.Respiratory physiology & neurobiology · 2018Article
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Authors and funding
5 authors.
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Abstract
Patients with heart failure (HF) display numerous derangements in ventilatory function, which together serve to increase the work of breathing (W(b)) during exercise. However, the extent to which the resistive and elastic properties of the respiratory system contribute to the higher W(b) in these patients is unknown. We quantified the resistive and elastic W(b) in patients with stable HF (n = 9; New York Heart Association functional class I-II) and healthy control subjects (n = 9) at standardised levels of minute ventilation (V'(E)) during graded exercise. Dynamic lung compliance was systematically lower for a given level of V'(E) in HF patients than controls (p<0.05). HF patients displayed slightly higher levels of inspiratory elastic W(b) with greater amounts of ventilatory constraint and resistive W(b) than control subjects during exercise (p<0.05). Our data indicates that the higher W(b) in HF patients is primarily due to a greater resistive, rather than elastic, load to breathing. The greater resistive W(b) in these patients probably reflects an increased hysteresivity of the airways and lung tissues. The marginally higher inspiratory elastic W(b) observed in HF patients appears related to a combined decrease in the compliances of the lungs and chest wall. The clinical and physiological implications of our findings are discussed.
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