ArticlePlant physiology2011
A soybean dual-specificity kinase, GmSARK, and its Arabidopsis homolog, AtSARK, regulate leaf senescence through synergistic actions of auxin and ethylene.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 97 citations in OpenAlex.
- The old nourishes the new: 100 years of leaf senescence studies in Plant Physiology.Plant physiology · 2026Review
- SnRK2.4 and SnRK2.10 redundantly control developmental leaf senescence by sustaining ABA production and signaling.Plant physiology · 2026Article
- Optimization of the Chemical Monoubiquitination System for Low-Solubility Protein: Achieving Balance Between Specificity and Yield.Current issues in molecular biology · 2026Article
- NInternational journal of molecular sciences · 2026Article
- The RING-type E3 ligase ATL72 positively regulates leaf senescence by monoubiquitinating the phosphatase SSPP to impair its dephosphorylation activity in Arabidopsis.Plant communications · 2025Article
- Identification of Auxin-Associated Genes in Wheat Through Comparative Transcriptome Analysis and Validation of the Candidate Receptor-like Kinase GenePlants (Basel, Switzerland) · 2025Article
- Identification and functional characterization of the MYB transcription factorFrontiers in plant science · 2025Article
- Analysis of the Mechanism of Wood Vinegar and Butyrolactone Promoting Rapeseed Growth and Improving Low-Temperature Stress Resistance Based on Transcriptome and Metabolomics.International journal of molecular sciences · 2024Article
- Identification of the early leaf senescence gene ELS3 in bread wheat (Triticum aestivum L.).Planta · 2023Article
- Receptor-like Kinases (LRR-RLKs) in Response of Plants to Biotic and Abiotic Stresses.Plants (Basel, Switzerland) · 2022Review
- Identification and Functional Analysis of Key Autophosphorylation Residues of Arabidopsis Senescence Associated Receptor-like Kinase.International journal of molecular sciences · 2022Article
- Know when and how to die: gaining insights into the molecular regulation of leaf senescence.Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Review
- Importance of Tyrosine Phosphorylation in Hormone-Regulated Plant Growth and Development.International journal of molecular sciences · 2022Review
- New Advances in the Regulation of Leaf Senescence by Classical and Peptide Hormones.Frontiers in plant science · 2022Review
- Function of Protein Kinases in Leaf Senescence of Plants.Frontiers in plant science · 2022Review
- Phosphoproteome analysis reveals the involvement of protein dephosphorylation in ethylene-induced corolla senescence in petunia.BMC plant biology · 2021Article
- Leaf senescence: progression, regulation, and application.Molecular horticulture · 2021Review
- Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots.Molecular systems biology · 2021Article
- Multiple Layers of Regulation on Leaf Senescence: New Advances and Perspectives.Frontiers in plant science · 2021Review
- Synergistic mutations of two rapeseed AHAS genes confer high resistance to sulfonylurea herbicides for weed control.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
As the last stage of leaf development, senescence is a fine-tuned process regulated by interplays of multiple signaling pathways. We have previously identified soybean (Glycine max) SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE (SARK), a leucine-rich repeat-receptor-like protein kinase from soybean, as a positive regulator of leaf senescence. Here, we report the elucidation of the molecular mechanism of GmSARK-mediated leaf senescence, especially its specific roles in senescence-inducing hormonal pathways. A glucocorticoid-inducible transcription system was used to produce transgenic Arabidopsis (Arabidopsis thaliana) plants for inducible overexpression of GmSARK, which led to early leaf senescence, chloroplast destruction, and abnormal flower morphology in Arabidopsis. Transcript analyses of the GmSARK-overexpressing seedlings revealed a multitude of changes in phytohormone synthesis and signaling, specifically the repression of cytokinin functions and the induction of auxin and ethylene pathways. Inhibition of either auxin action or ethylene biosynthesis alleviated the senescence induced by GmSARK. Consistently, mutation of either AUXIN RESISTANT1 or ETHYLENE INSENSITIVE2 completely reversed the GmSARK-induced senescence. We further identified a homolog of GmSARK with a similar expression pattern in Arabidopsis and named it AtSARK. Inducible overexpression of AtSARK caused precocious senescence and abnormal floral organ development nearly identical to the GmSARK-overexpressing plants, whereas a T-DNA insertion mutant of AtSARK showed significantly delayed senescence. A kinase assay on recombinant catalytic domains of GmSARK and AtSARK revealed that these two leucine-rich repeat-receptor-like protein kinases autophosphorylate on both serine/threonine and tyrosine residues. We inferred that the SARK-mediated pathway may be a widespread mechanism in regulating leaf senescence.
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