ReviewCurrent opinion in virology2011
Viva la revolución: rethinking influenza a virus antigenic drift.
Review in Current opinion in virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Seasonal influenza a virus lineages exhibit divergent abilities to antagonize interferon induction and signaling.PLoS pathogens · 2024Article
- Humoral Response to the Acetalated Dextran M2e Vaccine is Enhanced by Antigen Surface Conjugation.Bioconjugate chemistry · 2023Article
- The evolutionary potential of influenza A virus hemagglutinin is highly constrained by epistatic interactions with neuraminidase.Cell host & microbe · 2022Article
- Next-Generation Influenza Vaccines.Cold Spring Harbor perspectives in medicine · 2021Review
- Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for 'Universal' Influenza Vaccines.Vaccines · 2021Review
- Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site following Vaccination of Humans.Cell reports · 2019Article
- Sera from Individuals with Narrowly Focused Influenza Virus Antibodies Rapidly Select Viral Escape MutationsJournal of virology · 2018Article
- Article
- Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.Nature communications · 2018Article
- Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Deconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity.Microbiology and molecular biology reviews : MMBR · 2016Review
- Masking of antigenic epitopes by antibodies shapes the humoral immune response to influenza.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift during the 2014-2015 Influenza Season.Cell reports · 2015Article
- Antiviral B cell and T cell immunity in the lungs.Nature immunology · 2015Review
- Challenges of selecting seasonal influenza vaccine strains for humans with diverse pre-exposure histories.Current opinion in virology · 2014Review
- Recent H3N2 influenza virus clinical isolates rapidly acquire hemagglutinin or neuraminidase mutations when propagated for antigenic analyses.Journal of virology · 2014Article
- Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful.Archivum immunologiae et therapiae experimentalis · 2013Review
- Influenza A virus hemagglutinin trimerization completes monomer folding and antigenicity.Journal of virology · 2013Article
- Influenza viruses: breaking all the rules.mBio · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Rapid antigenic evolution of the influenza A virus hemagglutinin has precluded developing vaccines that provide durable protection. The yearly costs of influenza (circa $10(11) in the USA alone) easily justify investments in better understanding the interaction of influenza with antibodies and other inducible elements of the immune system that potentially limit or circumvent antigenic variation. Here, I summarize exciting new findings that offer the possibility of a quantum improvement in vaccine efficacy, focusing on studies clearly documenting robust neutralizing antibody responses to the conserved stem region of the hemagglutinin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.