Evidence map›Paper›PMID 22034525›Full record

ReviewBiology of reproduction2012

Roles of reactive oxygen species and antioxidants in ovarian toxicity.

Patrick J Devine, Sally D Perreault, Ulrike Luderer

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology of reproduction, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed, 2 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

181 citing papers in PubMed, 2 syntheses or guidelines pooled it, 419 citations in OpenAlex.

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121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Patrick J DevineNovartis Institute for BioMedical Research, Cambridge, Massachusetts, USA.
Sally D Perreault
Ulrike Luderer
Boston Biomedical Research Institute · USEnvironmental Protection Agency · USUniversity of California, Irvine · US

Funding

GSH: Protecting Ovarian Follicles from Oxidant InjuryK08ES010963 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LUDERER, ULRIKE · 2002 to 2006
$606k
Oxidative stress drives ovarian aging: modification by genetics and environmentR21AG032087 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LUDERER, ULRIKE · 2008 to 2009
$334k
CIHRNIA NIH HHS AG032087NIA NIH HHS R21 AG032087NIEHS NIH HHS ES10963NIEHS NIH HHS K08 ES010963
6 · The paper itself

Abstract

Proper functioning of the ovary is critical to maintain fertility and overall health, and ovarian function depends on the maintenance and normal development of ovarian follicles. This review presents evidence about the potential impact of oxidative stress on the well-being of primordial, growing and preovulatory follicles, as well as oocytes and early embryos, examining cell types and molecular targets. Limited data from genetically modified mouse models suggest that several antioxidant enzymes that protect cells from reactive oxygen species (ROS) may play important roles in follicular development and/or survival. Exposures to agents known to cause oxidative stress, such as gamma irradiation, chemotherapeutic drugs, or polycyclic aromatic hydrocarbons, induce rapid primordial follicle loss; however, the mechanistic role of ROS has received limited attention. In contrast, ROS may play an important role in the initiation of apoptosis in antral follicles. Depletion of glutathione leads to atresia of antral follicles in vivo and apoptosis of granulosa cells in cultured antral follicles. Chemicals, such as cyclophosphamide, dimethylbenzanthracene, and methoxychlor, increase proapoptotic signals, preceded by increased ROS and signs of oxidative stress, and cotreatment with antioxidants is protective. In oocytes, glutathione levels change rapidly during progression of meiosis and early embryonic development, and high oocyte glutathione at the time of fertilization is required for male pronucleus formation and for embryonic development to the blastocyst stage. Because current evidence suggests that oxidative stress can have significant negative impacts on female fertility and gamete health, dietary or pharmacological intervention may prove to be effective strategies to protect female fertility.

Indexed as

AnimalsAntioxidantsApoptosisFemaleFertilityMiceModels, AnimalOvarian FollicleOvaryOxidative StressReactive Oxygen SpeciesAntioxidantsReactive Oxygen Species

Identifiers

PMID22034525
PMCPMC3290661
OpenAlexW2130239194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.