ArticleArteriosclerosis, thrombosis, and vascular biology2012
In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Biomedical Imaging in Experimental Models of Cardiovascular Disease.Circulation research · 2022Review
- PEG-fibrinogen hydrogel microspheres as a scaffold for therapeutic delivery of immune cells.Frontiers in bioengineering and biotechnology · 2022Article
- Cardioprotective Potential of Human Endothelial-Colony Forming Cells from Diabetic and Nondiabetic Donors.Cells · 2020Article
- Fabrication of New Hybrid Scaffolds forFrontiers in cardiovascular medicine · 2020Article
- Optical fluorescence imaging with shortwave infrared light emitter nanomaterials for in vivo cell tracking in regenerative medicine.Journal of cellular and molecular medicine · 2019Review
- Article
- Delivery of progenitor cells with injectable shear-thinning hydrogel maintains geometry and normalizes strain to stabilize cardiac function after ischemia.The Journal of thoracic and cardiovascular surgery · 2019Article
- Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after myocardial infarction.Cardiovascular research · 2018Article
- Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix.Nature biomedical engineering · 2018Article
- Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties, being clonogenic, self-renewing, and multi-potent in vitro and in vivo.Stem cell research & therapy · 2017Article
- Removal from adherent culture contributes to apoptosis in human bone marrow mesenchymal stem cells.Molecular medicine reports · 2017Article
- Article
- Vascular stem cells-potential for clinical application.British medical bulletin · 2016Review
- A novel platelet lysate hydrogel for endothelial cell and mesenchymal stem cell-directed neovascularization.Acta biomaterialia · 2016Article
- Molecular Imaging for Comparison of Different Growth Factors on Bone Marrow-Derived Mesenchymal Stromal Cells' Survival and Proliferation In Vivo.BioMed research international · 2016Article
- Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium.The Journal of thoracic and cardiovascular surgery · 2015Article
- Microfluidic Single-Cell Analysis of Transplanted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes After Acute Myocardial Infarction.Circulation · 2015Article
- Attenuation of cardiac hypertrophy by G-CSF is associated with enhanced migration of bone marrow-derived cells.Journal of cellular and molecular medicine · 2015Article
- Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model.The American journal of sports medicine · 2015Article
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
objectiveClinical trials of bone marrow-derived stem cell therapy for the heart have yielded variable results. The basic mechanism(s) that underlies their potential efficacy remains unknown. In the present study, we evaluated the survival kinetics, transcriptional response, and functional outcome of intramyocardial bone marrow mononuclear cell (BMMC) transplantation for cardiac repair in a murine myocardial infarction model. METHODS AND
resultsWe used bioluminescence imaging and high-throughput transcriptional profiling to evaluate the in vivo survival kinetics and gene expression changes of transplanted BMMCs after their engraftment into ischemic myocardium. Our results demonstrate short-lived survival of cells following transplant, with less than 1% of cells surviving by 6 weeks posttransplantation. Moreover, transcriptomic analysis of BMMCs revealed nonspecific upregulation of various cell regulatory genes, with a marked downregulation of cell differentiation and maturation pathways. BMMC therapy caused limited improvement of heart function as assessed by echocardiography, invasive hemodynamics, and positron emission tomography. Histological evaluation of cell fate further confirmed findings of the in vivo cell tracking and transcriptomic analysis.
conclusionsCollectively, these data suggest that BMMC therapy, in its present iteration, may be less efficacious than once thought. Additional refinement of existing cell delivery protocols should be considered to induce better therapeutic efficacy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.