ArticleClinical journal of the American Society of Nephrology : CJASN2011
Risk of poor outcomes with novel and traditional biomarkers at clinical AKI diagnosis.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Trial
- Epoetin administrated after cardiac surgery: effects on renal function and inflammation in a randomized controlled study.BMC nephrology · 2012Trial
- External validation and comparative performance of four risk scores for acute kidney injury in critically ill adults.Renal failure · 2026Article
- Plasma exosomal microRNAs as early predictors of subclinical acute kidney injury in septic patients undergoing major non-cardiac surgery: a prospective observational cohort study.Scientific reports · 2026Observational
- Renal tubular epithelial cells as an easily accessible biomarker for diagnosing AKI post cardiac surgery.Intensive care medicine · 2025Article
- An updated approach to the evaluation of the urinary sediment.Pediatric nephrology (Berlin, Germany) · 2025Review
- Caloric and time restriction diets improve acute kidney injury in experimental menopausal rats: role of silent information regulator 2 homolog 1 and transforming growth factor beta 1.Molecular biology reports · 2024Article
- Predictive Performance of Neutrophil Gelatinase Associated Lipocalin, Liver Type Fatty Acid Binding Protein, and Cystatin C for Acute Kidney Injury and Mortality in Severely Ill Patients.Annals of laboratory medicine · 2024Article
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery.BMC nephrology · 2023Article
- The effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise.BMC nephrology · 2022Article
- Urine Sediment Exam Provides More Diagnostic Information in AKI than Novel Urinary Biomarkers: PRO.Kidney360 · 2022Article
- The effects of two different dietary regimens during exercise on outcome of experimental acute kidney injury.Journal of inflammation (London, England) · 2022Article
- Effects of caloric and time restriction diets on kidney health in rat model of postmenopausal acute kidney injury: An apoptosis and histopathological study.Iranian journal of basic medical sciences · 2022Article
- Using urinary neutrophile gelatinase-associated lipocalin for prognosticate renal dysfunction in children with familial Mediterranean fever the study design: a pilot study.Advances in rheumatology (London, England) · 2021Article
- Urine microscopy as a biomarker of Acute Kidney Injury following cardiac surgery with cardiopulmonary bypass.Jornal brasileiro de nefrologia · 2020Observational
- Is urine microscopy a useful early biomarker for cardiac surgeryrelated AKI?Jornal brasileiro de nefrologia · 2020Article
- Troponin I at admission in the intensive care unit predicts the need of dialysis in septic patients.BMC nephrology · 2018Observational
- Urinary biomarkers predict advanced acute kidney injury after cardiovascular surgery.Critical care (London, England) · 2018Article
- Perspective on Clinical Application of Biomarkers in AKI.Journal of the American Society of Nephrology : JASN · 2017Review
- Profiling of Kidney Injury Biomarkers in Patients Receiving Cisplatin: Time-dependent Changes in the Absence of Clinical Nephrotoxicity.Clinical pharmacology and therapeutics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
BACKGROUND AND
objectivesStudies have evaluated acute kidney injury (AKI) using biomarkers in various settings, but their prognostic utility within current practice is unclear. Thus, we sought to determine the prognostic utility of newer biomarkers or traditional markers (fractional excretion of sodium [FeNa] and urea [FeUrea] and microscopy) over clinical assessment alone. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This is a prospective cohort study of adults on the first day of meeting AKI criteria. We measured urine concentrations of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and IL-18 and determined FeNa, FeUrea, and microscopy score for casts and tubular cells. Primary outcome was worsened AKI stage from enrollment to peak serum creatinine or in-hospital death.
resultsIn 249 recipients, 57% were ≥65 years old, 48% were from intensive care, and mean baseline GFR was 69 ± 30 ml/min per 1.73 m(2). AKI was considered prerenal in 164 (66%), acute tubular necrosis (ATN) in 51 (20%), and "other" in 34 (14%). All mean protein biomarker concentrations, FeNa, FeUrea, and microscopy scores were statistically different between prerenal and ATN. Seventy-two patients (29%) developed the primary outcome. There was an approximate three-fold increase in adjusted risk for the outcome for upper versus lower values of NGAL, KIM-1, IL-18, and microscopy score (P values <0.05). Net reclassification improved after adding these to baseline clinical assessment. FeNa and FeUrea were not useful.
conclusionsOn the first day of AKI, urine protein biomarkers and microscopy significantly improve upon clinical determination of prognosis, indicating their potential utility in current practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.