ArticleNucleic acids research2012
Yeast mitochondrial RNase P, RNase Z and the RNA degradosome are part of a stable supercomplex.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- RNA Polymerase III Promoters Compatible with CRISPR Gene Regulation inACS synthetic biology · 2025Article
- The molecular machinery for maturation of primary mtDNA transcripts.Human molecular genetics · 2024Review
- Mitochondrial RNA maturation.RNA biology · 2024Review
- How RNases Shape Mitochondrial Transcriptomes.International journal of molecular sciences · 2022Review
- ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.Nature cell biology · 2021Article
- Ccm1p is a 15S rRNA primary transcript processing factor as elucidated by a novel in vivo system in Saccharomyces cerevisiae.Current genetics · 2020Article
- TheRNA (New York, N.Y.) · 2018Article
- Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2.Protein & cell · 2017Article
- Amazing structure of respirasome: unveiling the secrets of cell respiration.Protein & cell · 2016Review
- Partial suppression of the respiratory defect of qrs1/her2 glutamyl-tRNA amidotransferase mutants by overexpression of the mitochondrial pentatricopeptide Msc6p.Current genetics · 2016Article
- Multiple Layers of Stress-Induced Regulation in tRNA Biology.Life (Basel, Switzerland) · 2016Review
- SUV3 helicase is required for correct processing of mitochondrial transcripts.Nucleic acids research · 2015Article
- RNA sociology: group behavioral motifs of RNA consortia.Life (Basel, Switzerland) · 2014Review
- Massive programmed translational jumping in mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria.Nucleic acids research · 2014Article
- tRNA 3' processing in yeast involves tRNase Z, Rex1, and Rrp6.RNA (New York, N.Y.) · 2014Article
- Transfer RNA post-transcriptional processing, turnover, and subcellular dynamics in the yeast Saccharomyces cerevisiae.Genetics · 2013Review
- Yeast PPR proteins, watchdogs of mitochondrial gene expression.RNA biology · 2013Article
- Rarely at rest: RNA helicases and their busy contributions to RNA degradation, regulation and quality control.RNA biology · 2013Review
- The mitochondrial RNA landscape of Saccharomyces cerevisiae.PloS one · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Initial steps in the synthesis of functional tRNAs require 5'- and 3'-processing of precursor tRNAs (pre-tRNAs), which in yeast mitochondria are achieved by two endonucleases, RNase P and RNase Z. In this study, using a combination of detergent-free Blue Native Gel Electrophoresis, proteomics and in vitro testing of pre-tRNA maturation, we reveal the physical association of these plus other mitochondrial activities in a large, stable complex of 136 proteins. It contains a total of seven proteins involved in RNA processing including RNase P and RNase Z, five out of six subunits of the mitochondrial RNA degradosome, components of the fatty acid synthesis pathway, translation, metabolism and protein folding. At the RNA level, there are the small and large rRNA subunits and RNase P RNA. Surprisingly, this complex is absent in an oar1Δ deletion mutant of the type II fatty acid synthesis pathway, supporting a recently published functional link between pre-tRNA processing and the FAS II pathway--apparently by integration into a large complex as we demonstrate here. Finally, the question of mt-RNase P localization within mitochondria was investigated, by GFP-tracing of a known protein subunit (Rpm2p). We find that about equal fractions of RNase P are soluble versus membrane-attached.
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