Evidence map›Paper›PMID 22034223›Full record

ArticleThe Laryngoscope2011

Health state utility values in patients undergoing endoscopic sinus surgery.

Zachary M Soler, Eve Wittenberg, Rodney J Schlosser, Jess C Mace, Timothy L Smith

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Guideline
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  5. Chronic rhinosinusitis: an under-researched epidemic.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2015
    Pooled it
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  7. Trial
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  15. Balloon sinuplasty: does a model simulator improve ENT trainee competence?Annals of the Royal College of Surgeons of England · 2026
    Article
  16. Article
  17. Article
  18. Expression of Proliferating Cell Nuclear Antigen (PCNA) in Nasal Polyp: A Systematic Review and Meta-analysis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  19. The Diagnosis and Treatment of Chronic Rhinosinusitis.Deutsches Arzteblatt international · 2024
    Review
  20. The value of biomarkers in the therapy of CRSwNP with biologicals-a long-term follow-up of dupilumab therapy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zachary M SolerDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Eve Wittenberg
Rodney J Schlosser
Jess C Mace
Timothy L Smith

Funding

DETERMINANTS OF SURGICAL OUTCOMES IN CHRONIC SINUSITISR01DC005805 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI SMITH, TIMOTHY L, SOLER, ZACHARY M · 2004 to 2020
$7.6M
NIDCD NIH HHS R01 DC005805NIDCD NIH HHS R01DC005805-05
6 · The paper itself

Abstract

objectives/hypothesisThe primary study goal was to measure health state utility values in patients with chronic rhinosinusitis (CRS) before and after undergoing endoscopic sinus surgery (ESS). A secondary goal was to assess the meaning of these values by comparing them with other chronic disease processes and currently available medical or surgical treatments. STUDY

designProspective, observational cohort study.

methodsAdults with CRS were enrolled after electing ESS and were observed for a 5-year period. Baseline demographic and medical comorbidities were recorded for each patient, as well as findings from computed tomography (CT), endoscopy, olfaction, and disease-specific quality of life scores. Utility values were derived using the Short-Form 6D (SF-6D) at baseline and again after surgery.

resultsThe mean SF-6D utility value for the baseline health state of all patients with CRS (n = 232) was 0.65 (95% confidence interval [CI]: 0.63-0.66). Baseline utility values correlated with disease-specific quality of life as measured by the Rhinosinusitis Disability Index (r = -0.660; P < .001), but not baseline CT, endoscopy, or olfactory scores. Follow-up utility values (≥ 6 months) after ESS improved by 0.087 (95% CI: 0.06-0.12; P < .001) in patients with no history of sinus surgery and 0.062 (95% CI: 0.04-0.09; P < .001) in those undergoing a revision procedure.

conclusionsPatients with CRS who failed medical therapy and elected to undergo ESS reported health state utility values that were significantly lower than the US population norm. Utility values showed improvement after ESS, which was statistically and clinically significant. These results provide the initial data necessary for formal cost-effectiveness analyses incorporating ESS.

Indexed as

Health Status IndicatorsAdolescentAdultAgedChronic DiseaseCohort StudiesConfidence IntervalsEndoscopyFemaleFollow-Up StudiesHealth StatusHumansMaleMiddle AgedParanasal Sinus DiseasesPatient Selection

Identifiers

PMID22034223
PMCPMC3232034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.