ArticleThe Journal of biological chemistry2011
Conformational dynamics of the plug domain of the SecYEG protein-conducting channel.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Article
- Driving Forces of Translocation Through Bacterial Translocon SecYEG.The Journal of membrane biology · 2018Article
- The Sec System: Protein Export inEcoSal Plus · 2017Review
- Protein export through the bacterial Sec pathway.Nature reviews. Microbiology · 2017Review
- Ion conductivity of the bacterial translocation channel SecYEG engaged in translocation.The Journal of biological chemistry · 2014Article
- Membrane protein insertion and proton-motive-force-dependent secretion through the bacterial holo-translocon SecYEG-SecDF-YajC-YidC.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex.Nature structural & molecular biology · 2014Article
- Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.Nature · 2014Article
- Functional asymmetry within the Sec61p translocon.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The bacterial translocon SecYEG opens upon ribosome binding.The Journal of biological chemistry · 2013Article
- YidC occupies the lateral gate of the SecYEG translocon and is sequentially displaced by a nascent membrane protein.The Journal of biological chemistry · 2013Article
- Direct simulation of early-stage Sec-facilitated protein translocation.Journal of the American Chemical Society · 2012Article
- The bacterial Sec-translocase: structure and mechanism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Competitive binding of the SecA ATPase and ribosomes to the SecYEG translocon.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central pore of the SecYEG preprotein-conducting channel is closed at the periplasmic face of the membrane by a plug domain. To study its conformational dynamics, the plug was labeled site-specifically with an environment-sensitive fluorophore. In the presence of a stable preprotein translocation inter-mediate, the SecY plug showed an enhanced solvent exposure consistent with a displacement from the hydrophobic central pore region. In contrast, binding and insertion of a ribosome-bound nascent membrane protein did not alter the plug conformation. These data indicate different plug dynamics depending on the ligand bound state of the SecYEG channel.
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Registered trials
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