ReviewWorld journal of surgery2012
Metabolic and nutritional support of the enterocutaneous fistula patient: a three-phase approach.
Review in World journal of surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines.Intensive care medicine · 2017Guideline
- Pooled it
- Analyse of patient characteristics and aetiological causes of enterocutaneous fistulas and their impacts on in-hospital mortality: a ten-year retrospective cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Gastrointestinal Fistulas-What Gastroenterologists Need to Know in 2025.Canadian journal of gastroenterology & hepatology · 2025Review
- Entero-Cutaneous and Entero-Atmospheric Fistulas: Insights into Management Using Negative Pressure Wound Therapy.Journal of clinical medicine · 2024Review
- A review of platelet-rich plasma for enteric fistula management.Frontiers in bioengineering and biotechnology · 2023Review
- Therapeutic Options in Postoperative Enterocutaneous Fistula-A Retrospective Case Series.Medicina (Kaunas, Lithuania) · 2022Article
- THE ROLE OF FISTULOCLYSIS IN THE TREATMENT OF PATIENTS WITH ENTEROATMOSPHERIC FISTULAS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2021Review
- Technique Advances in Enteroatmospheric Fistula Isolation After Open Abdomen: A Review and Outlook.Frontiers in surgery · 2020Review
- Nutritional Management of Patients With Enterocutaneous Fistulas: Practice and Progression.Frontiers in nutrition · 2020Review
- A technique to establish fistuloclysis for high-output jejunocutaneous fistula through percutaneous enterostomy: A case report.Medicine · 2019Article
- The open abdomen in trauma and non-trauma patients: WSES guidelines.World journal of emergency surgery : WJES · 2018Review
- Postoperative enterocutaneous fistula - principles in non-operative approach.Annals of medicine and surgery (2012) · 2017Article
- Management of Intestinal Failure: The High-Output Enterostomy and Enterocutaneous Fistula.Clinics in colon and rectal surgery · 2017Review
- The role of open abdomen in non-trauma patient: WSES Consensus Paper.World journal of emergency surgery : WJES · 2017Review
- Enterocutaneous Fistula: Proven Strategies and Updates.Clinics in colon and rectal surgery · 2016Review
- Practical Approaches to Definitive Reconstruction of Complex Abdominal Wall Defects.World journal of surgery · 2016Review
- Classification, prevention and management of entero-atmospheric fistula: a state-of-the-art review.Langenbeck's archives of surgery · 2016Review
- Reducing pre-operative length of stay for enterocutaneous fistula repair with a multi-disciplinary approach.BMJ quality improvement reports · 2015Article
- Surgical Tips in Frozen Abdomen Management: Application of Coliseum Technique.Case reports in surgery · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe care and outcome of enterocutaneous fistula (ECF) have improved greatly over several decades due to revolutionary advances in nutrition, along with dramatic improvements in the treatment of sepsis and the critically ill. However, as the collective experience with damage control surgery has matured, the frequent development of enteroatmospheric fistula (EAF) in the "open abdomen" patient has emerged as an even more vexing problem. Despite our best efforts, ECF and especially EAF continue to be highly morbid conditions, and sepsis and malnutrition remain the leading causes of death. Aggressive nutritional and metabolic support is the most significant predictor of outcome with ECF and EAF.
resultsDiscussion of the historical advances in nutritional therapy and their impact on ECF, as well as review of the classification of ECF and EAF, provides a framework for the suggested phased strategy that specifically targets the nutritional and metabolic needs of the ECF/EAF patient. These three phases include (1) diagnosis, resuscitation, and early interval nutrition; (2) definition of fistula anatomy, drainage of collections, nutritional assessment and monitoring, and placement of feeding access; and (3) definitive nutritional management, including pharmacologic adjuncts. Early nutritional support with parenteral nutrition followed by transition to enteral nutrition is advocated, including the merits of delivery of enteral nutrition via the fistula itself, known as fistuloclysis.
conclusionAggressive nutritional therapy is necessary to reverse the catabolic state associated with ECF/EAF patients. Once established, it allows proper time, preparation, and planning for definitive management of the fistula, and in many cases provides the support for spontaneous closure.
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