ArticleArchives of virology2012
Recombination and positive selection identified in complete genome sequences of Japanese encephalitis virus.
Article in Archives of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Global population dynamics and evolutionary selection in classical swine fever virus complete genomes: insights from Bayesian coalescent analysis.Virus genes · 2025Article
- Genetic diversity of Murray Valley encephalitis virus 1951-2020 identified via phylogenetic and evolutionary analyses.PLoS neglected tropical diseases · 2025Article
- A specific domain within the 3' untranslated region of Usutu virus confers resistance to the exonuclease ISG20.Nature communications · 2024Article
- Comparative genomics of Japanese encephalitis virus shows low rates of recombination and a small subset of codon positions under episodic diversifying selection.PLoS neglected tropical diseases · 2024Article
- The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes.PLoS neglected tropical diseases · 2023Article
- Widespread interspecific phylogenetic tree incongruence between mosquito-borne and insect-specific flaviviruses at hotspots originally identified in Zika virus.Virus evolution · 2022Article
- Molecular epidemiology of mosquito-borne viruses at the China-Myanmar border: discovery of a potential epidemic focus of Japanese encephalitis.Infectious diseases of poverty · 2021Article
- Population genomics of louping ill virus provide new insights into the evolution of tick-borne flaviviruses.PLoS neglected tropical diseases · 2020Article
- Review
- Full-Genome Characterization and Genetic Evolution of West African Isolates of Bagaza Virus.Viruses · 2018Article
- Nonstructural Proteins Are Preferential Positive Selection Targets in Zika Virus and Related Flaviviruses.PLoS neglected tropical diseases · 2016Article
- Comparison of genotypes I and III in Japanese encephalitis virus reveals distinct differences in their genetic and host diversity.Journal of virology · 2014Article
- Spatiotemporal characterizations of dengue virus in mainland China: insights into the whole genome from 1978 to 2011.PloS one · 2014Article
- Cell type-dependent RNA recombination frequency in the Japanese encephalitis virus.BioMed research international · 2014Article
- Japanese encephalitis virus in India: An update on virus genotypes.The Indian journal of medical researchReview
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Authors and funding
4 authors at 2 institutions in 3 countries.
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Abstract
The mosquito-borne Japanese encephalitis virus (JEV) causes encephalitis in man but not in pigs. Complete genomes of a human, mosquito and pig isolate from outbreaks in 1982 and 1985 in Thailand were sequenced with the aim of identifying determinants of virulence that may explain the differences in outcomes of JEV infection between pigs and man. Phylogenetic analysis revealed that five of these isolates belonged to genotype I, but the 1982 mosquito isolate belonged to genotype III. There was no evidence of recombination among the Thai isolates, but there were phylogenetic signals suggestive of recombination in a 1994 Korean isolate (K94P05). Two sites of the genome under positive selection were identified: codons 996 and 2296 (amino acids 175 of the non-structural protein NS1 and 24 of NS4B, respectively). A structurally significant substitution was seen at NS4B position 24 of the human isolate compared with the mosquito and pig isolates from the 1985 outbreak in Thailand. The potential importance of the two sites in the evolution and ecology of JEV merits further investigation.
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