ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
The intramuscular contribution to the slow oxygen uptake kinetics during exercise in chronic heart failure is related to the severity of the condition.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- A novel cardiopulmonary exercise test protocol and criterion to determine maximal oxygen uptake in chronic heart failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Trial
- How Priming Exercise Affects Oxygen Uptake Kinetics: From Underpinning Mechanisms to Endurance Performance.Sports medicine (Auckland, N.Z.) · 2023Review
- Skeletal Muscle Tissue Saturation Changes Measured Using Near Infrared Spectroscopy During Exercise Are Associated With Post-Occlusive Reactive Hyperaemia.Frontiers in physiology · 2022Article
- Salutary Acute Effects of Exercise on Central Hemodynamics in Heart Failure With Preserved Ejection Fraction.Journal of cardiac failure · 2021Article
- Short-Term Changes in Quality of Life in Patients with Advanced Lung Cancer during In-Hospital Exercise Training and Chemotherapy Treatment: A Randomized Controlled Trial.Journal of clinical medicine · 2021Article
- Effects of Blood Flow Restriction on OFrontiers in physiology · 2021Article
- Evaluating the suitability of supra-POAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Chronic heart failure with diabetes mellitus is characterized by a severe skeletal muscle pathology.Journal of cachexia, sarcopenia and muscle · 2020Article
- Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure.Journal of cachexia, sarcopenia and muscle · 2020Article
- Left Ventricular Assist Device Support Complicates the Exercise Physiology of Oxygen Transport and Uptake in Heart Failure.Cardiac failure review · 2019Review
- Exercise limitations in heart failure with reduced and preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Pulmonary Rehabilitation and Palliative Care for the Lung Cancer Patient.Journal of hospice and palliative nursing : JHPN : the official journal of the Hospice and Palliative Nurses Association · 2015Article
- Does impaired O2 delivery during exercise accentuate central and peripheral fatigue in patients with coexistent COPD-CHF?Frontiers in physiology · 2014Article
- Mitochondrial function and increased convective O2 transport: implications for the assessment of mitochondrial respiration in vivo.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Effect of moderate-intensity work rate increment on phase II τVO₂, functional gain and Δ[HHb].European journal of applied physiology · 2013Article
- Mitochondrial activation at the onset of contractions in isolated myofibres during successive contractile periods.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism for slow pulmonary O(2) uptake (Vo(2)) kinetics in patients with chronic heart failure (CHF) is unclear but may be due to limitations in the intramuscular control of O(2) utilization or O(2) delivery. Recent evidence of a transient overshoot in microvascular deoxygenation supports the latter. Prior (or warm-up) exercise can increase O(2) delivery in healthy individuals. We therefore aimed to determine whether prior exercise could increase muscle oxygenation and speed Vo(2) kinetics during exercise in CHF. Fifteen men with CHF (New York Heart Association I-III) due to left ventricular systolic dysfunction performed two 6-min moderate-intensity exercise transitions (bouts 1 and 2, separated by 6 min of rest) from rest to 90% of lactate threshold on a cycle ergometer. Vo(2) was measured using a turbine and a mass spectrometer, and muscle tissue oxygenation index (TOI) was determined by near-infrared spectroscopy. Prior exercise increased resting TOI by 5.3 ± 2.4% (P = 0.001), attenuated the deoxygenation overshoot (-3.9 ± 3.6 vs. -2.0 ± 1.4%, P = 0.011), and speeded the Vo(2) time constant (τVo(2); 49 ± 19 vs. 41 ± 16 s, P = 0.003). Resting TOI was correlated to τVo(2) before (R(2) = 0.51, P = 0.014) and after (R(2) = 0.36, P = 0.051) warm-up exercise. However, the mean response time of TOI was speeded between bouts in half of the patients (26 ± 8 vs. 20 ± 8 s) and slowed in the remainder (32 ± 11 vs. 44 ± 16 s), the latter group having worse New York Heart Association scores (P = 0.042) and slower Vo(2) kinetics (P = 0.001). These data indicate that prior moderate-intensity exercise improves muscle oxygenation and speeds Vo(2) kinetics in CHF. The most severely limited patients, however, appear to have an intramuscular pathology that limits Vo(2) kinetics during moderate exercise.
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