ArticleJournal of immunological methods2012
Translocation capture sequencing: a method for high throughput mapping of chromosomal rearrangements.
Article in Journal of immunological methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Decoding DNA metabolism and its clinical relevance through the lens of high-throughput sequencing assays.Medical review (2021) · 2026Review
- DNA Damage Atlas: an atlas of DNA damage and repair.Nucleic acids research · 2024Article
- Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model.International journal of molecular sciences · 2023Review
- Prediction of CRISPR-Cas9 off-target activities with mismatches and indels based on hybrid neural network.Computational and structural biotechnology journal · 2023Article
- Review
- Gene editing in the context of an increasingly complex genome.BMC genomics · 2018Review
- Article
- RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks.The Journal of experimental medicine · 2017Article
- Epigenetic targeting of activation-induced cytidine deaminase.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Functional chromatin features are associated with structural mutations in cancer.BMC genomics · 2014Article
- Article
- Highly divergent integration profile of adeno-associated virus serotype 5 revealed by high-throughput sequencing.Journal of virology · 2014Article
- Adeno-associated virus type 2 preferentially integrates single genome copies with defined breakpoints.Virology journal · 2014Article
- Genome engineering using the CRISPR-Cas9 system.Nature protocols · 2013Article
- High-throughput sequencing reveals principles of adeno-associated virus serotype 2 integration.Journal of virology · 2013Article
- 53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma.Molecular cell · 2013Article
- Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.Advances in cancer research · 2012Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Chromosomal translocations require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are involved in producing leukemias, lymphomas and sarcomas. Translocations are frequent, clonal and recurrent in mature B cell lymphomas, which bear a particularly high DNA damage burden by virtue of activation-induced cytidine deaminase (AID) expression. Despite the ubiquity of genomic rearrangements, the forces that underlie their genesis are not well understood. Here, we provide a detailed description of a new method for studying these events, translocation capture sequencing (TC-Seq). TC-Seq provides the means to document chromosomal rearrangements genome-wide in primary cells, and to discover recombination hotspots. Demonstrating its effectiveness, we successfully estimate the frequency of c-myc/IgH translocations in primary B cells, and identify hotspots of AID-mediated recombination. Furthermore, TC-Seq can be adapted to generate genome-wide rearrangement maps in any cell type and under any condition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.