ArticleMayo Clinic proceedings2011
Association between low serum 25-hydroxyvitamin D and depression in a large sample of healthy adults: the Cooper Center longitudinal study.
Article in Mayo Clinic proceedings, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 4 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Vitamin D and depression in adults: A systematic review.Biomolecules & biomedicine · 2025Pooled it
- Effect of vitamin D supplementation on the incidence and prognosis of depression: An updated meta-analysis based on randomized controlled trials.Frontiers in public health · 2022Pooled it
- Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws.Nutrients · 2014Pooled it
- Serum 25-hydroxyvitamin D levels and the risk of depression: a systematic review and meta-analysis.The journal of nutrition, health & aging · 2013Pooled it
- Effect of Vitamin D on Paraxonase-1, Total Antioxidant Capacity, and 8-Isoprostan in Children with Attention Deficit Hyperactivity Disorder.International journal of clinical practice · 2022Trial
- Markers of vitamin D metabolism and premenstrual symptoms in healthy women with regular cycles.Human reproduction (Oxford, England) · 2021Trial
- Vitamin D3 supplementation and treatment outcomes in patients with depression (D3-vit-dep).BMC research notes · 2019Trial
- Dose ranging effects of vitamin D3 on the geriatric depression score: A clinical trial.The Journal of steroid biochemistry and molecular biology · 2018Trial
- A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers.BMC pregnancy and childbirth · 2016Trial
- Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial.BMC psychiatry · 2016Trial
- Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial.Maturitas · 2015Trial
- Association Between Low Vitamin D Levels and Depression: A Systematic Review and Meta-Analysis.Cureus · 2026Review
- A comprehensive review of dietary supplements mission-specific health and performance enhancement in military soldiers.Food science and biotechnology · 2025Review
- Vitamin-mediated interaction between the gut microbiome and mitochondria in depression: A systematic review-based integrated perspective.Brain, behavior, & immunity - health · 2024Review
- The Non-conventional Effects of Hypovitaminosis D: A Pandemic Even in Sunlight-Rich Countries.Cureus · 2024Review
- Article
- Cardiorespiratory fitness and depression symptoms among adults during the COVID-19 Pandemic: Cooper Center Longitudinal Study.Preventive medicine reports · 2022Article
- Article
- Relationship between the double burden of malnutrition and mental health in overweight and obese adult women.Journal of nutritional science · 2022Article
- Vitamin D and the Risks of Depression and Anxiety: An Observational Analysis and Genome-Wide Environment Interaction Study.Nutrients · 2021Observational
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between serum vitamin D levels and depression in a large database of patients from the Cooper Clinic. PATIENTS AND
methodsWe conducted a cross-sectional study of 12,594 participants seen at the Cooper Clinic from November 27, 2006, to October 4, 2010. Serum 25-hydroxyvitamin D [25(OH)D] was analyzed, and depression was defined as a Center for Epidemiologic Studies Depression Scale (CES-D) score of 10 or more. Those with and those without a history of depression represented 2 distinct populations with respect to CES-D scores; accordingly, they were analyzed separately.
resultsIn the total sample, higher vitamin D levels were associated with a significantly decreased risk [odds ratio, 0.92 (95% confidence interval, 0.87-0.97)] of current depression based on CES-D scores. The finding was stronger in those with a prior history of depression [odds ratio, 0.90 (95% confidence interval, 0.82-0.98)] and not significant in those without a history of depression [odds ratio, 0.95 (95% confidence interval, 0.89-1.02)].
conclusionWe found that low vitamin D levels are associated with depressive symptoms, especially in persons with a history of depression. These findings suggest that primary care patients with a history of depression may be an important target for assessment of vitamin D levels.
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