ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2012
Dynamic changes in oxygenation of intracranial tumor and contralateral brain during tumor growth and carbogen breathing: a multisite EPR oximetry with implantable resonators.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Electron paramagnetic resonance (EPR) meets drug delivery and biomaterials: a magnetic love story.Drug delivery and translational research · 2026Review
- Review
- Evaluation of a Refined Implantable Resonator for Deep-Tissue EPR Oximetry in the Clinic.Applied magnetic resonance · 2021Article
- Wireless implantable coil with parametric amplification for in vivo electron paramagnetic resonance oximetric applications.Magnetic resonance in medicine · 2018Article
- Dynamic EPR Oximetry of Changes in Intracerebral Oxygen Tension During Induced Thromboembolism.Cell biochemistry and biophysics · 2017Article
- Development of the Implantable Resonator System for Clinical EPR Oximetry.Cell biochemistry and biophysics · 2017Article
- FMISO-PET-derived brain oxygen tension maps: application to glioblastoma and less aggressive gliomas.Scientific reports · 2017Article
- Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Using Stable Free Radicals to Obtain Unique and Clinically Useful Data In Vivo in Human Subjects.Radiation protection dosimetry · 2016Review
- Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications.Advances in experimental medicine and biology · 2016Article
- Spatial oxygenation profiles in tumors during normo- and hyperbaric hyperoxia.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2015Article
- A review of flux considerations for in vivo neurochemical measurements.The Analyst · 2015Review
- Monitoring oxygen levels in orthotopic human glioma xenograft following carbogen inhalation and chemotherapy by implantable resonator-based oximetry.International journal of cancer · 2015Article
- Article
- Real-time monitoring of ischemic and contralateral brain pO2 during stroke by variable length multisite resonators.Magnetic resonance imaging · 2014Article
- Clinical EPR: unique opportunities and some challenges.Academic radiology · 2014Review
- Advances in probes and methods for clinical EPR oximetry.Advances in experimental medicine and biology · 2014Review
- Article
- Skeletal muscle and glioma oxygenation by carbogen inhalation in rats: a longitudinal study by EPR oximetry using single-probe implantable oxygen sensors.Advances in experimental medicine and biology · 2014Article
- Real-time, in vivo determination of dynamic changes in lung and heart tissue oxygenation using EPR oximetry.Advances in experimental medicine and biology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
introductionSeveral techniques currently exist for measuring tissue oxygen; however technical difficulties have limited their usefulness and general application. We report a recently developed electron paramagnetic resonance (EPR) oximetry approach with multiple probe implantable resonators (IRs) that allow repeated measurements of oxygen in tissue at depths of greater than 10mm.
methodsThe EPR signal to noise (S/N) ratio of two probe IRs was compared with that of LiPc deposits. The feasibility of intracranial tissue pO(2) measurements by EPR oximetry using IRs was tested in normal rats and rats bearing intracerebral F98 tumors. The dynamic changes in the tissue pO(2) were assessed during repeated hyperoxia with carbogen breathing.
resultsA 6-10 times increase in the S/N ratio was observed with IRs as compared to LiPc deposits. The mean brain pO(2) of normal rats was stable and increased significantly during carbogen inhalation in experiments repeated for 3months. The pO(2) of F98 glioma declined gradually, while the pO(2) of contralateral brain essentially remained the same. Although a significant increase in the glioma pO(2) was observed during carbogen inhalation, this effect declined in experiments repeated over days.
conclusionEPR oximetry with IRs provides a significant increase in S/N ratio. The ability to repeatedly assess orthotopic glioma pO(2) is likely to play a vital role in understanding the dynamics of tissue pO(2) during tumor growth and therapies designed to modulate tumor hypoxia. This information could then be used to optimize chemoradiation by scheduling treatments at times of increased glioma oxygenation.
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