Digesting new information about the role of trypsin in pancreatitis.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed.

1. Proapoptotic Peptide Brush Polymer Nanoparticles via Photoinitiated Polymerization-Induced Self-Assembly.Angewandte Chemie (International ed. in English) · 2020
   Article
2. Transgenic Expression of PRSS1Gastroenterology · 2020
   Article
3. Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017
   Review
4. A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis.The Journal of biological chemistry · 2016
   Article
5. Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2016
   Review
6. Nucleotide-binding oligomerization domain 1 acts in concert with the cholecystokinin receptor agonist, cerulein, to induce IL-33-dependent chronic pancreatitis.Mucosal immunology · 2016
   Article
7. Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death.Cell death & disease · 2014
   Article
8. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.The Journal of clinical investigation · 2013
   Article
9. Beneficial effects of trypsin inhibitors derived from a spider venom peptide in L-arginine-induced severe acute pancreatitis in mice.PloS one · 2013
   Article
10. Autophagy and pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2012
    Review
11. Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.Immunity · 2012
    Article

Corrections and comments

• Comment on
  Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis.2011

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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