ArticleVirology journal2011
Increased HCMV seroprevalence in patients with hepatocellular carcinoma.
Article in Virology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Trial
- Memory inflation: Beyond the acute phase of viral infection.Cell proliferation · 2024Review
- Molecular characterization of plasma virome of hepatocellular carcinoma (HCC) patients.AMB Express · 2024Article
- Multifocal EBV-associated smooth muscle tumors in a patient with cytomegalovirus infection after liver transplantation: a case report from Shiraz, Iran.Diagnostic pathology · 2022Article
- CMV Seropositive Status Increases Heparanase SNPs Regulatory Activity, Risk of Acute GVHD and Yield of CD34Cells · 2021Article
- Patients withOncology letters · 2021Article
- An atlas of the tissue and blood metagenome in cancer reveals novel links between bacteria, viruses and cancer.Microbiome · 2021Article
- Factors associated with cytomegalovirus serostatus in young people in England: a cross-sectional study.BMC infectious diseases · 2020Article
- The emerging role of human cytomegalovirus infection in human carcinogenesis: a review of current evidence and potential therapeutic implications.Oncotarget · 2019Review
- The prevalence of EBV and CMV DNA in epithelial ovarian cancer.Infectious agents and cancer · 2019Article
- The impact of inflationary cytomegalovirus-specific memory T cells on anti-tumour immune responses in patients with cancer.Immunology · 2018Review
- Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes.Oncotarget · 2017Article
- The influence of HCMV infection on autophagy in THP-1 cells.Medicine · 2017Article
- Increased incidence of cytomegalovirus coinfection in HCV-infected patients with late liver fibrosis is associated with dysregulation of JAK-STAT pathway.Scientific reports · 2017Article
- Cytomegalovirus, Macrophages and Breast Cancer.The open virology journal · 2017Review
- Human Cytomegalovirus DNA Quantification and Gene Expression in Gliomas of Different Grades.PloS one · 2016Article
- The decoy Fcγ receptor encoded by the cytomegalovirus UL119-UL118 gene has differential affinity to IgG proteins expressing different GM allotypes.Human immunology · 2015Article
- Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options.World journal of experimental medicine · 2015Review
- The oncogenic potential of human cytomegalovirus and breast cancer.Frontiers in oncology · 2014Review
- Seropositivity and higher immunoglobulin g antibody levels against cytomegalovirus are associated with mortality in the population-based European prospective investigation of Cancer-Norfolk cohort.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatocellular carcinoma (HCC) is the most common primary liver cancer, usually arising after years of chronic liver inflammation that could result from viral infections such as hepatitis B virus (HBV) and hepatitic C virus (HCV) infections. Human cytomegalovirus (HCMV) infects primary human hepatocytes and remains an important cause of morbidity in immunocompromised persons where it may manifest as symptomatic end-organ disease including hepatitis. The goal of the present study was to determine a potential correlation between HCMV infection and the appearance of HCC.
methodsFirst, we analyzed the seroprevalence of HCMV in a cohort of 11,318 patients hospitalized between 2003 and 2009 in different departments of a French University Hospital. Second, we studied HCMV seroprevalence in a cohort of 190 subjects who were stratified on the basis of age, gender, HCC, cirrhosis (Cir), and the exposition to hepatotropic viruses (HCV, HBV). We further determined whether HCMV DNA was present specifically in tumour area in liver biopsies from HCC-positive patients by using nested PCR.
resultsWe found that the HCMV seroprevalence was high in the Hepatology department. The HCMV seroprevalence was significantly higher in patients infected with HCV and/or HBV than in patients who were not infected by those later viruses (76.2% versus 56.5%, p < 0.001). The HCMV seroprevalence was significantly higher in patients with HCC (74%) and lower in patients without HCC (54% for HCC-/Cir+ patients, 57% for HCC-/Cir- subjects). We observed a positive correlation between serum IL-6 levels and HCMV seroprevalence in cirrhotic patients, but not in HCC patients. Serum IL-6 levels correlated positively with C-reactive protein (CRP) levels. Preliminary histological studies from liver biopsies from HCC-positive patients highlighted that HCMV DNA can be detected in tumour area of some of the patients studied.
conclusionsOur results indicate that HCMV seroprevalence in patients with HCC is significantly higher than in patients without HCC, is positively correlated with serum IL-6 levels in cirrhotic patients, and is positively associated with the presence of other hepatotropic viruses such as HCV and HBV.
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