Evidence map›Paper›PMID 22032400›Full record

ArticleAnnals of the New York Academy of Sciences2011

Advancing drug discovery for schizophrenia.

Stephen R Marder, Bryan Roth, Patrick F Sullivan, Edward M Scolnick, Eric J Nestler, Mark A Geyer, Daniel R Welnberger, Maria Karayiorgou, Alessandro Guidotti, Jay Gingrich and 15 more

Erratum issuedOpen access · greenAbstract readConference Proceedings
In one paragraph

Article in Annals of the New York Academy of Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  6. Review
  7. ΔFosB induction in prefrontal cortex by antipsychotic drugs is associated with negative behavioral outcomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
    Article
  8. Article
  9. Review
  10. DISC1 as a therapeutic target for mental illnesses.Expert opinion on therapeutic targets · 2012
    Review
  11. Effect of valproic acid on mitochondrial epigenetics.European journal of pharmacology · 2012
    Article
  12. Article
4 · The record

Corrections and comments

  • Erratum issued
    Saw, Akira [corrected to Sawa, Akira]
5 · Who and what money

Authors and funding

25 authors at 15 institutions in 2 countries.

Stephen R MarderSemel Institute for Neuroscience at the University of California, Los Angeles, California, USA.
Bryan Roth
Patrick F Sullivan
Edward M Scolnick
Eric J Nestler
Mark A Geyer
Daniel R Welnberger
Maria Karayiorgou
Alessandro Guidotti
Jay Gingrich
Schahram Akbarian
Robert W Buchanan
Jeffrey A Lieberman
P Jeffrey Conn
Stephen J Haggarty
Amanda J Law
Brian Campbell
John H Krystal
Bita Moghaddam
Akira Sawa
Akira Saw
Marc G Caron
Susan R George
John A Allen
Michelle Solis
Pfizer (United States) · USColumbia University · USDuke University Hospital · USJohns Hopkins Medicine · USMount Sinai Medical Center · USNew York Psychoanalytic Society and Institute · USNew York State Psychiatric InstituteSchizophrenia Research Foundation · INUniversity of California, Los Angeles · USUniversity of California, San Diego · USUniversity of Illinois Chicago · USUniversity of Maryland, Baltimore · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · USYale University · US

Funding

FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPESR01NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 1993 to 2025
$6.2M
RECEPTORS MEDIATING DRUG DEPENDENCER01DA007223 · NIDA · UNIVERSITY OF TORONTO · PI GEORGE, SUSAN R · 1991 to 2013
$2.5M
Functional Genomics of Neuroplasticity in SchizophreniaR01MH095088 · NIMH · BROAD INSTITUTE, INC. · PI HAGGARTY, STEPHEN J · 2011 to 2014
$2.5M
NIDA NIH HHS R01 DA007223NIMH NIH HHS R01 MH095088NINDS NIH HHS R01 NS031373
6 · The paper itself

Abstract

Sponsored by the New York Academy of Sciences and with support from the National Institute of Mental Health, the Life Technologies Foundation, and the Josiah Macy Jr. Foundation, "Advancing Drug Discovery for Schizophrenia" was held March 9-11 at the New York Academy of Sciences in New York City. The meeting, comprising individual talks and panel discussions, highlighted basic, clinical, and translational research approaches, all of which contribute to the overarching goal of enhancing the pharmaceutical armamentarium for treating schizophrenia. This report surveys work by the vanguard of schizophrenia research in such topics as genetic and epigenetic approaches; small molecule therapeutics; and the relationships between target genes, neuronal function, and symptoms of schizophrenia.

Indexed as

AnimalsAntipsychotic AgentsDisease Models, AnimalDrug DiscoveryEpigenomicsGenome-Wide Association StudyHumansModels, BiologicalMolecular Targeted TherapyNew YorkResearchResearch DesignSchizophreniaAntipsychotic Agents

Identifiers

PMID22032400
PMCPMC3787879
OpenAlexW1492606176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.