ArticleCurrent biology : CB2011
Transcriptional repressors: shutting off gene expression at the source affects developmental dynamics.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
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- Complex cis-regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator.Development (Cambridge, England) · 2016Article
- Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.PloS one · 2014Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental networks feature genes interlinked by transcriptional activation and repression. A new study indicates that repressors can 'shut the door' to newly initiating polymerases, allowing longer target genes to produce latent transcripts after shorter genes have been effectively silenced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.