ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
An improved model for the rate-level functions of auditory-nerve fibers.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- A Fundamental Inequality Governing the Rate Coding Response of Sensory Neurons.Biological cybernetics · 2023Article
- The burst gap is a peripheral temporal code for pitch perception that is shared across audition and touch.Scientific reports · 2022Article
- Computational principles of neural adaptation for binaural signal integration.PLoS computational biology · 2020Article
- Phase Locking of Auditory Nerve Fibers: The Role of Lowpass Filtering by Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Phase Locking of Auditory-Nerve Fibers Reveals Stereotyped Distortions and an Exponential Transfer Function with a Level-Dependent Slope.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Cochlear compound action potentials from high-level tone bursts originate from wide cochlear regions that are offset toward the most sensitive cochlear region.Journal of neurophysiology · 2019Article
- Cochlear Synaptopathy Changes Sound-Evoked Activity Without Changing Spontaneous Discharge in the Mouse Inferior Colliculus.Frontiers in systems neuroscience · 2018Article
- Pulse trains to percepts: the challenge of creating a perceptually intelligible world with sight recovery technologies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Stochastic undersampling steepens auditory threshold/duration functions: implications for understanding auditory deafferentation and aging.Frontiers in aging neuroscience · 2015Article
- A model of synaptic vesicle-pool depletion and replenishment can account for the interspike interval distributions and nonrenewal properties of spontaneous spike trains of auditory-nerve fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Towards a unifying basis of auditory thresholds: binaural summation.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Why do I hear but not understand? Stochastic undersampling as a model of degraded neural encoding of speech.Frontiers in neuroscience · 2014Review
- Why longer song elements are easier to detect: threshold level-duration functions in the Great Tit and comparison with human data.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Perception of stochastically undersampled sound waveforms: a model of auditory deafferentation.Frontiers in neuroscience · 2013Article
- Detection of Near-Threshold Sounds is Independent of EEG Phase in Common Frequency Bands.Frontiers in psychology · 2013Article
- Article
- Responsiveness of the Electrically Stimulated Cochlear Nerve in Children With Cochlear Nerve Deficiency.Ear and hearingArticle
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acoustic information is conveyed to the brain by the spike patterns in auditory-nerve fibers (ANFs). In mammals, each ANF is excited via a single ribbon synapse in a single inner hair cell (IHC), and the spike patterns therefore also provide valuable information about those intriguing synapses. Here we reexamine and model a key property of ANFs, the dependence of their spike rates on the sound pressure level of acoustic stimuli (rate-level functions). We build upon the seminal model of Sachs and Abbas (1974), which provides good fits to experimental data but has limited utility for defining physiological mechanisms. We present an improved, physiologically plausible model according to which the spike rate follows a Hill equation and spontaneous activity and its experimentally observed tight correlation with ANF sensitivity are emergent properties. We apply it to 156 cat ANF rate-level functions using frequencies where the mechanics are linear and find that a single Hill coefficient of 3 can account for the population of functions. We also demonstrate a tight correspondence between ANF rate-level functions and the Ca(2+) dependence of exocytosis from IHCs, and derive estimates of the effective intracellular Ca(2+) concentrations at the individual active zones of IHCs. We argue that the Hill coefficient might reflect the intrinsic, biochemical Ca(2+) cooperativity of the Ca(2+) sensor involved in exocytosis from the IHC. The model also links ANF properties with properties of psychophysical absolute thresholds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.