Evidence map›Paper›PMID 22031874›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2011

Prefrontal transcranial direct current stimulation changes connectivity of resting-state networks during fMRI.

Daniel Keeser, Thomas Meindl, Julie Bor, Ulrich Palm, Oliver Pogarell, Christoph Mulert, Jerome Brunelin, Hans-Jürgen Möller, Maximilian Reiser, Frank Padberg

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 271 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
271citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02715128 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Disorder-tailored Transcranial Direct Current Stimulation (tDCS) of the Prefrontal Cortex: fMRI Study in Major Depression and Schizophrenia

TypeinterventionalSponsorLudwig-Maximilians - University of MunichRan2016 to 2022Enrolled30ConditionsMajor Depressive Disorder, SchizophreniaArmsTranscranial direct current stimulation (tDCS)
NCT03843203 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Efficacy and Effectivity of Long Term Home Based tDCS in Fibromyalgia: an Explanatory Randomized Clinical Trial

TypeinterventionalSponsorHospital de Clinicas de Porto AlegreRan2018 to 2021Enrolled84ConditionsFibromyalgia, Transcranial Direct Current StimulationArmsTranscranial Direct Current Stimulation - tDCS
NCT05845528 nacompletednot on this mapstarted 2021, after this paper: background citation

Impact of Susceptibility to Placebo on the Effect of Transcranial Direct Current Stimulation (tDCS) in Fibromyalgia: a Randomized Clinical Trial With Extended Home Stimulation

TypeinterventionalSponsorHospital de Clinicas de Porto AlegreRan2021 to 2024Enrolled100ConditionsFibromyalgiaArmss-tDCS, a- tDCS
3 · Its place in the literature

Who cites it

271 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  4. Brain stimulation for patients with multiple sclerosis: an umbrella review of therapeutic efficacy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  18. Prefrontal cortex stimulation prevents stress-induced HPA axis reactivity in people at familial risk of schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2025
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211 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel KeeserDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians University, 80333 Munich, Germany.
Thomas Meindl
Julie Bor
Ulrich Palm
Oliver Pogarell
Christoph Mulert
Jerome Brunelin
Hans-Jürgen Möller
Maximilian Reiser
Frank Padberg

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) has been proposed for experimental and therapeutic modulation of regional brain function. Specifically, anodal tDCS of the dorsolateral prefrontal cortex (DLPFC) together with cathodal tDCS of the supraorbital region have been associated with improvement of cognition and mood, and have been suggested for the treatment of several neurological and psychiatric disorders. Although modeled mathematically, the distribution, direction, and extent of tDCS-mediated effects on brain physiology are not well understood. The current study investigates whether tDCS of the human prefrontal cortex modulates resting-state network (RSN) connectivity measured by functional magnetic resonance imaging (fMRI). Thirteen healthy subjects underwent real and sham tDCS in random order on separate days. tDCS was applied for 20 min at 2 mA with the anode positioned over the left DLPFC and the cathode over the right supraorbital region. Patterns of resting-state brain connectivity were assessed before and after tDCS with 3 T fMRI, and changes were analyzed for relevant networks related to the stimulation-electrode localizations. At baseline, four RSNs were detected, corresponding to the default mode network (DMN), the left and right frontal-parietal networks (FPNs) and the self-referential network. After real tDCS and compared with sham tDCS, significant changes of regional brain connectivity were found for the DMN and the FPNs both close to the primary stimulation site and in connected brain regions. These findings show that prefrontal tDCS modulates resting-state functional connectivity in distinct functional networks of the human brain.

Indexed as

Brain MappingTranscranial Magnetic StimulationAdultDouble-Blind MethodHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysOxygenPrefrontal CortexPrincipal Component AnalysisReaction TimeRestYoung AdultOxygen

Identifiers

PMID22031874
PMCPMC6703525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.