ArticleWorld journal of biological chemistry2011
Mechanisms of autophagy and apoptosis: Recent developments in breast cancer cells.
Article in World journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- The Function of Autophagy in the Initiation, and Development of Breast Cancer.Current medicinal chemistry · 2024Review
- Lysosomes as a Target of Anticancer Therapy.International journal of molecular sciences · 2023Review
- Photothermal effect of albumin-modified gold nanorods diminished neuroblastoma cancer stem cells dynamic growth by modulating autophagy.Scientific reports · 2022Article
- K092A and K092B, Two Peptides Isolated from the Dogfish (Marine drugs · 2019Article
- Ethanol extract of Chrysanthemum zawadskii Herbich induces autophagy and apoptosis in mouse colon cancer cells through the regulation of reactive oxygen species.BMC complementary and alternative medicine · 2019Article
- A Potential Antineoplastic Peptide of Human Prostate Cancer Cells Derived from the Lesser Spotted Dogfish (Marine drugs · 2019Article
- Inhibiting autophagy increases epirubicin's cytotoxicity in breast cancer cells.Cancer science · 2016Article
- IKKβ/NFκBp65 activated by interleukin-13 targets the autophagy-related genes LC3B and beclin 1 in fibroblasts co-cultured with breast cancer cells.Experimental and therapeutic medicine · 2016Article
- Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells.OncoTargets and therapy · 2016Article
- Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids.PloS one · 2015Article
- The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.The Journal of biological chemistry · 2014Article
- Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death.Biochemical pharmacology · 2014Article
- Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response.Cell death & disease · 2013Article
- Article
- Molecular mechanism of SAHA on regulation of autophagic cell death in tamoxifen-resistant MCF-7 breast cancer cells.International journal of medical sciences · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy, the pathway whereby cell components are degraded by lysosomes, is involved in the cell response to environmental stresses, such as nutrient deprivation, hypoxia or exposition to chemotherapeutic agents. Under these conditions, which are reminiscent of certain phases of tumor development, autophagy either promotes cell survival or induces cell death. This strengthens the possibility that autophagy could be an important target in cancer therapy, as has been proposed. Here, we describe the regulation of survival and death by autophagy and apoptosis, especially in cultured breast cancer cells. In particular, we discuss whether autophagy represents an apoptosis-independent process and/or if they share common pathways. We believe that understanding in detail the molecular mechanisms that underlie the relationships between autophagy and apoptosis in breast cancer cells could improve the available treatments for this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.