ArticleJournal of neurophysiology2012
Contribution of intrinsic properties and synaptic inputs to motoneuron discharge patterns: a simulation study.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Reverse engineering of motor unit discharge in multiple sclerosis reveals heterogeneity of voluntary motor commands.medRxiv : the preprint server for health sciences · 2026Article
- The Soleus H-Reflex as a Biomarker of Post-Injury Spasticity in Spinal Cord Injury: A Conceptual Pilot Study.NeuroRehabilitation · 2025Article
- Pathophysiology of voluntary motor commands at the level of the spinal motoneuron in patients with multiple sclerosis.medRxiv : the preprint server for health sciences · 2025Article
- Multiple patterns of persistent inward currents with multiple types of repetitive firings in medullary serotonergic neurons of mice: An experimental and modeling study.PLoS computational biology · 2025Article
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- Relationships among motor unit discharge parameters used to estimate synaptic inputs to motoneurons.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Onion skin is not a universal firing pattern for spinal motoneurons: simulation study.Journal of neurophysiology · 2024Article
- Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents: A simulation study.PLoS computational biology · 2024Article
- Motor unit firing rate modulation is more impaired during flexion synergy-driven contractions of the biceps brachii in chronic stroke.medRxiv : the preprint server for health sciences · 2023Article
- Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023Review
- A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on individual motor unit discharge patterns.Journal of neural engineering · 2023Article
- Spinal stimulation for motor rehabilitation immediately modulates nociceptive transmission.Journal of neural engineering · 2022Article
- The control and training of single motor units in isometric tasks are constrained by a common input signal.eLife · 2022Article
- Cholinergic modulation of persistent inward currents is mediated by activating muscarinic receptors of serotonergic neurons in the brainstem of ePet-EYFP mice.Experimental brain research · 2022Article
- Locomotor Pattern and Force Generation Modulated by Ionic Channels: A Computational Study of Spinal Networks Underlying Locomotion.Frontiers in computational neuroscience · 2022Article
- The effects of membrane potential oscillations on the excitability of rat hypoglossal motoneurons.Frontiers in physiology · 2022Article
- The Cellular Basis for the Generation of Firing Patterns in Human Motor Units.Advances in neurobiology · 2022Article
- Firing rate trajectories of human occipitofrontalis motor units in response to triangular voluntary contraction intensity.Experimental brain research · 2021Article
- Estimates of persistent inward currents are reduced in upper limb motor units of older adults.The Journal of physiology · 2021Article
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4 authors.
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Abstract
Motoneuron discharge patterns reflect the interaction of synaptic inputs with intrinsic conductances. Recent work has focused on the contribution of conductances mediating persistent inward currents (PICs), which amplify and prolong the effects of synaptic inputs on motoneuron discharge. Certain features of human motor unit discharge are thought to reflect a relatively stereotyped activation of PICs by excitatory synaptic inputs; these features include rate saturation and de-recruitment at a lower level of net excitation than that required for recruitment. However, PIC activation is also influenced by the pattern and spatial distribution of inhibitory inputs that are activated concurrently with excitatory inputs. To estimate the potential contributions of PIC activation and synaptic input patterns to motor unit discharge patterns, we examined the responses of a set of cable motoneuron models to different patterns of excitatory and inhibitory inputs. The models were first tuned to approximate the current- and voltage-clamp responses of low- and medium-threshold spinal motoneurons studied in decerebrate cats and then driven with different patterns of excitatory and inhibitory inputs. The responses of the models to excitatory inputs reproduced a number of features of human motor unit discharge. However, the pattern of rate modulation was strongly influenced by the temporal and spatial pattern of concurrent inhibitory inputs. Thus, even though PIC activation is likely to exert a strong influence on firing rate modulation, PIC activation in combination with different patterns of excitatory and inhibitory synaptic inputs can produce a wide variety of motor unit discharge patterns.
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