ArticleThe Journal of experimental biology2011
Mechanisms of stable lipid loss in a social insect.
Article in The Journal of experimental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 120 citations in OpenAlex.
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- Gut microbiota-derived butyrate primes systemic immunity in honey bees by mediating lipid metabolic reprogramming.Nature communications · 2026Article
- Synergistic effects of pollen grains on several vital life parameters of Amblyseius swirskii when preying upon Tetranychus urticae.Scientific reports · 2025Article
- Nature's blueprint for sugar metabolism: translating bee and ant strategies into human diabetes therapies.Diabetology & metabolic syndrome · 2025Review
- Comparative Transcriptome Analysis of the Effects of a Non-Insect Artificial Diet on the Nutritional Development ofInsects · 2025Article
- Sequence-Based Multi Ancestry Association Study Reveals the Polygenic Architecture of Varroa destructor Resistance in the Honeybee Apis mellifera.Molecular ecology · 2025Article
- A novel Fish Protein Hydrolysate supplement enhances honey bee foraging activity and colony strength: A pilot study.PloS one · 2025Article
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- Effects of microRNA-305 knockdown on brain gene expression associated with division of labor in honey bee colonies (Apis mellifera).The Journal of experimental biology · 2024Article
- The effects of queen mandibular pheromone on nurse-aged honey bee (Apis mellifera) hypopharyngeal gland size and lipid metabolism.PloS one · 2024Article
- Carbohydrate nutrition associated with health of overwintering honey bees.Journal of insect science (Online) · 2023Article
- Sterol and lipid metabolism in bees.Metabolomics : Official journal of the Metabolomic Society · 2023Review
- Histone acetyltransferases and external demands influence task switching inBiology letters · 2023Article
- Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior.Scientific reports · 2023Article
- Antibiotics Alter the Expression of Genes Related to Behavioral Development in Honey Bees (Hymenoptera: Apidae).Journal of insect science (Online) · 2022Article
- Transcriptional expression of mFrontiers in cell and developmental biology · 2022Article
- Pollen nutrition fosters honeybee tolerance to pesticides.Royal Society open science · 2021Article
- Segmentation of the subcuticular fat body in Apis mellifera females with different reproductive potentials.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Worker honey bees undergo a socially regulated, highly stable lipid loss as part of their behavioral maturation. We used large-scale transcriptomic and proteomic experiments, physiological experiments and RNA interference to explore the mechanistic basis for this lipid loss. Lipid loss was associated with thousands of gene expression changes in abdominal fat bodies. Many of these genes were also regulated in young bees by nutrition during an initial period of lipid gain. Surprisingly, in older bees, which is when maximum lipid loss occurs, diet played less of a role in regulating fat body gene expression for components of evolutionarily conserved nutrition-related endocrine systems involving insulin and juvenile hormone signaling. By contrast, fat body gene expression in older bees was regulated more strongly by evolutionarily novel regulatory factors, queen mandibular pheromone (a honey bee-specific social signal) and vitellogenin (a conserved yolk protein that has evolved novel, maturation-related functions in the bee), independent of nutrition. These results demonstrate that conserved molecular pathways can be manipulated to achieve stable lipid loss through evolutionarily novel regulatory processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.